Randomized phase 3 trial of prophylactic cranial irradiation for patients with extensive small-cell lung cancer
Not Applicable
- Conditions
- Extensive small-cell lung cancer patients with no brain metastasis who had a response to platinum-based first-line chemotherapy,
- Registration Number
- JPRN-UMIN000001755
- Lead Sponsor
- Yamamoto Group, Grant for Cancer Research, Ministry of Health, Labour, and Welfare
- Brief Summary
PCI does not prolong overall survival in extensive-disease small-cell lung cancer patients.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 330
Inclusion Criteria
Not provided
Exclusion Criteria
1. Previous radiotherapy to the head and neck area overlapped with PCI field. 2. Another active cancer 3. Serious psychological and/or physiological complications 4. An expectant or lactating woman
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Overall survival
- Secondary Outcome Measures
Name Time Method Incidence of brain metastasis, Time to brain metastasis, Progression free survival, Adverse events