Aerosolized Antibiotics in Mechanically Ventilated Patients
Overview
- Phase
- Phase 2
- Intervention
- Not specified
- Conditions
- Ventilator Associated Pneumonia
- Sponsor
- Stony Brook University
- Enrollment
- 80
- Locations
- 1
- Primary Endpoint
- Ventilator associated pneumonia Systemic Antibiotic use Clinical pulmonary infection score
- Status
- Completed
- Last Updated
- 19 years ago
Overview
Brief Summary
The purpose of this study was to determine the effect of aerosolized antibiotics on respiratory infection in mechanically ventilated patients.We hypothesize that aerosolized antibiotics , which achieve high drug concentrations in the airway, would more effectively treat respiratory infection, decrease the need for systemic antibiotics and decrease antibiotic resistance.
Detailed Description
In patients requiring mechanical ventilation, signs of respiratory infection often persist despite treatment with powerful antibiotics given through the patient's vein. In this trial, patients with purulent secretions were assigned aerosolized antibiotics or placebo by a randomizing protocol. Neither the patients or their doctors knew what the patient was receiving.Need for a systemic antibiotic was determined by the clinical physician. Comparisons were made between placebo and study drug for their effects on pneumonia, respiratory signs of infection, ability to wean patients from the ventilator, systemic(given in the vein) antibiotic use and the development of organisms that were resistant to antibiotics.
Investigators
Eligibility Criteria
Inclusion Criteria
- •be on mechanical ventilation greater than 3 days
- •greater than or equal to 18 years of age survival greater than 14 days
- •greater than 2 ccs of tracheal secretions/4 hours
Exclusion Criteria
- •allergy to drugs, pregnancy
Outcomes
Primary Outcomes
Ventilator associated pneumonia Systemic Antibiotic use Clinical pulmonary infection score
Secondary Outcomes
- Weaning from mechanical ventilation Bacterial resistance