Bronchial Washing Beforeand After Endobronchial Biopsy and Bronchial Brushing
- Conditions
- Lung Cancer
- Registration Number
- NCT05569629
- Lead Sponsor
- Chinese University of Hong Kong
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 118
Inclusion Criteria:<br><br> - Patients who are eligible for bronchoscopy and endoscopic sampling procedures (i.e.<br> endobronchial biopsy (EBBx), bronchial brushing (BB) and bronchial washing (BW)) as<br> recommended by the prevailing local guideline<br><br> - Patients will undergo endoscopic sampling procedures to the airway that contains the<br> endoscopically visible tumours<br><br> - Patients who are aged 18 years old or above<br><br> - Patients are cognitively capable to consent for the procedure and the study<br><br> - Patients with endoscopically visible tumours in the airway during bronchoscopy, that<br> can be approached by endoscopic sampling procedures<br><br> - Only those visible lesions with endoscopic morphology of tumorous, infiltrative,<br> necrotic-coated types will be included<br><br>Exclusion Criteria:<br><br> - Endoscopically visible tumours are not expected based on pre-bronchoscopy imaging<br> (e.g. CT thorax)<br><br> - Failed to obtain informed consent due to patient's refusal or cognitive impairment<br><br> - Bronchoscopy that will be performed in an emergency situation that precludes a<br> detailed examination or prolonged procedure time, e.g. massive haemoptysis<br><br> - The prevailing contraindications for bronchoscopy or bronchoscopic samplings, e.g.<br> uncorrected coagulopathy, and uncontrolled respiratory failure<br><br> - Lesions with an anticipated high risk of severe bleeding are found, e.g. carcinoid<br> tumour, Dieulafoy's lesion and Kaposi sarcoma<br><br> - The targeted lesion is located in the trachea or carina<br><br> - Patients with tumours morphology of submucosal type or extrinsic compressions, or<br> with a normal mucosal appearance in the targeted airway<br><br> - Technical reasons precluding an optimal sampling of the lesion by endoscopic<br> sampling procedures, including sharp angulation of the airway and patient<br> intolerance<br><br> - Excessive bleeding due to EBBx and BB causing difficult procedure of subsequent BW<br> or premature termination of the procedure<br><br> - Coexisting tumours in the same lobar or segmental bronchi, either proximal or distal<br> to the targeted lesion, as it is impossible to distinguish the source of exfoliated<br> cells<br><br> - A total volume of more than 100mL of normal saline is instilled for the first BW in<br> the combined BW group, as the total amount of normal saline after the two BW<br> procedures may exceed 200mL and impose a risk of impaired gaseous exchange
Not provided
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To compare the diagnostic yield of bronchial washing in confirming malignancy (intergroup comparison)
- Secondary Outcome Measures
Name Time Method To compare the diagnostic yield of bronchial washing in confirming malignancy (intragroup comparison);To compare the cell adequacy in the bronchial washing cytology specimens;To compare the time spent for endoscopic sampling procedures;To compare the occurrence of bleeding complications during endoscopic sampling procedures