Clinical Comparison of Application of Curcumin Gel in Pain Management After Free Gingival Graft Harvesting

Not Applicable

Recruiting

• Conditions: Palate; Wound
• Interventions: Other: curcumin gel 2%

• Registration Number: NCT05819632
• Lead Sponsor: Cairo University

Brief Summary

The aim of this study is to compare the effect of using 2% curcumin gel versus gelatin sponge when applied to palatal donor site in pain management and wound healing after free gingival graft harvesting.

Detailed Description

Not available

Study Timeline

• Study Start: 2022-11-01
• Study First Submitted: 2023-03-03
• Status Verified: 2023-04
• Study First Submitted QC: 2023-04-15
• Last Update Submitted: 2023-04-15
• Study First Posted: 2023-04-19
• Last Update Posted: 2023-04-19
• Primary Completion: 2024-02-01
• Study Completion: 2024-04-01

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

1. Systematically healthy patient (American Society of Anesthesiology class I and II).
2. Male or female
3. Patients with mucogingival defects scheduled for free gingival graft.
4. Patients with good oral hygiene.

Exclusion Criteria

1. Patients with any uncontrolled local or systemic disease where periodontal plastic surgery might be contraindicated.
2. History of recent periodontal surgery at the donor site.
3. Smokers.
4. Pregnancy and lactation.
5. Patients allergic to the used agents,
6. Severe gagging reflex.
7. Inability or unwillingness to provide informed consent.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
curcumin gel	curcumin gel 2%	the denuded palatal area will be superficially covered with a continuous thin layer of curcumin gel 2% one time immediately after the surgery (curcumin gel will be prepared in 2% concentration on a carbapol base)according to (Bhatia et al., 2014)
gelatine sponge	curcumin gel 2%	absorbable gelatin sponge will be cut to the palatal wound size and applied. Following manual compression of the wound area, both agents will be secured in place using compressive palatal sling sutures. commercial name (CUTANPLAST)

Primary Outcome Measures

Name	Time	Method
post-operative pain	one week post operative	post -operative pain measured by visual analouge scale from 0 (no pain) to 10 (highest pain value)

Secondary Outcome Measures

Name	Time	Method
Re-epithelization of the palatal wound	up to three weeks post-operative	Re-epithelization of the palatal wound using H2O2 test
Soft tissue healing of the palatal wound	up to three weeks post-operative	Soft tissue healing of the palatal wound measured by Modified Landry's wound healing score from 1 indicates poorest healing to 5 indicates excellent healing

Trial Locations

Locations (1)

Faculty of Dentistry; 🇪🇬 Cairo, Manial, Egypt