Effects of Beef Consumption on Skeletal Muscle Protein Homeostasis and Inflammatory Factors in Pre- and Postmenopausal Females
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 65
- 试验地点
- 1
- 主要终点
- Net change in muscle protein synthesis (% per day).
研究概览
简要总结
This will be a randomized study to determine if animal-based protein-rich food sources can stimulate greater muscle protein turnover and whole-body protein balance and reduce skeletal muscle inflammatory markers in postmenopausal women compared to vegetarian base protein-rich foods.
详细描述
A randomized cross-sectional controlled trial will be conducted to quantify whole-body and muscle protein turnover and skeletal muscle inflammation following 5-days of consumption of either beef or isonitrogenous plant-based sources of protein in normal/overweight and obese post-menopausal females. A premenopausal normal/overweight group consuming beef containing study meals will also be recruited to serve as a healthy control comparison.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Other
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 35 Years 至 65 Years（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Postmenopausal women ages 50-65 (absence of menstruation for at least 12 months).
- •Premenopausal women ages 35-45 (presence of normal monthly menstruation for the past 12 months).
- •BMI of 20.0 - 34.9 kg/m
- •COVID-19 negative and/or asymptomatic
排除标准
- •Any substantial musculoskeletal injuries/diseases that have limited daily activities in the past month.
- •Unable to stop the use of anti-inflammatory drugs for the week prior to and during study.
- •Diagnosed metabolic or hormonal disease (i.e., renal, cardiovascular, thyroid, polycystic ovary syndrome, or type I/II diabetes mellitus).
- •Currently pregnant.
- •Gave birth or was lactating within previous 12 months.
- •Undergone gastric bypass/bariatric surgery.
- •Clinically significant weight gain or loss (>5% change) in the last 12 months.
- •Consuming metabolism-altering drugs or medications (i.e., corticosteroids, stimulants, insulin, thyroid medication).
- •Unable or unwilling to suspend anti-clotting medications including aspirin use for 5 days prior to Visit
- •Participating in >200 minutes/week of vigorous exercise and/or >4 days/week of resistance training.
- •Unwilling to fast overnight.
- •Surgical menopause.
- •Having undergone hormone replacement therapy in the last 12 months.
研究组 & 干预措施
premenopausal with normal/overweight BMI that eats primarily beef as their protein source
干预措施: meals consisting of primarily animal protein sources (Other)
postmenopausal with normal/overweight BMI that eats primarily beef as their protein source
干预措施: meals consisting of primarily animal protein sources (Other)
postmenopausal with normal/overweight BMI that eats vegetables as their protein source
干预措施: meals consisting of plant protein sources (Other)
postmenopausal with obese BMI that eats primarily beef as their protein source in study meals
干预措施: meals consisting of primarily animal protein sources (Other)
postmenopausal with obese BMI that eats vegetables as their protein source in study meals
干预措施: meals consisting of plant protein sources (Other)
结局指标
主要结局
Net change in muscle protein synthesis (% per day).
时间窗: Study meals are eaten for 5 consecutive days.
Change in net muscle protein synthesis between groups.
次要结局
未报告次要终点