A Study of Vaginal MicroFlora and Immune Profiles of Patients With Recurrent Urinary Tract Infection
- Conditions
- Urinary Tract Infections
- Registration Number
- NCT00216853
- Lead Sponsor
- Lawson Health Research Institute
- Brief Summary
The purpose of this study is to determine the extent to which vaginal microflora and immune profiles of patients with urinary tract infection (UTI) differ from healthy controls.
- Detailed Description
Recurrent urinary tract infections, which occur mostly in the female population, can be potentially harmful if not treated and significantly reduce quality of life. By characterizing the vaginal microflora and immune profiles of women that suffer recurrent UTIs in contrast to a healthy age matched normal group of women (with no history of recurrent UTIs), we can better understand the differences. This in turn can lead to development of better quality probiotics that will be based on their scientific basis, clinical efficacy, and quality in terms of shelf life and delivery to target sites. The reduction in only one third of UTI cases seen each year would have a significant impact on reducing health care costs.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 44
Inclusion Criteria for UTI Group:
- At least 2 recurrent UTIs within the last year
- Written informed consent
Inclusion Criteria for Normal Group:
- No UTI within the past 5 years
- Written informed consent
Exclusion Criteria for Both Groups:
- Active UTI
- Urinary tract anomalies
- Evidence of a neurogenic bladder
- Known immunodeficiencies
- Use of antibiotics, within the last month
- Concomitant use of oral steroids
- Known renal calculi
- Previous or ongoing chemotherapy
- Pregnancy
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
St. Joseph's Health Centre
🇨🇦London, Ontario, Canada