Antibiotic Exposure During Pregnancy Affects Infant Gut Microbiota
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Antibiotics Affecting Newborn Gut Microbiota
- Sponsor
- Peking University People's Hospital
- Enrollment
- 450
- Locations
- 1
- Primary Endpoint
- Infant gut microbiome
- Status
- Recruiting
- Last Updated
- last year
Overview
Brief Summary
Based on a prospective birth cohort, the investigators will collect biological samples from participants including pregnant women and newborns, to measure the gut microbial diversity and metabolites of newborns. These results systematically evaluate the effects of antibiotic exposure on the structure and function of gut microbiota. The project can reveal the effects of antibiotic exposure on the growth and development of gut microbiota in early life.
Investigators
xu xue
Vice Chief Physician
Peking University People's Hospital
Eligibility Criteria
Inclusion Criteria
- •Pregnant woman
- •aged 20-40 years old
- •natural conception
- •single pregnancy
- •gestational age ≥36 weeks
- •normal Apgar score
- •no serious congenital diseases
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
Infant gut microbiome
Time Frame: Pregnancy (12, 24, 37 weeks) and infants (born, 1 week, and 1, 3, 6, 12 months)
* Diversity of gut microbiota * Abundance of antibiotic resistance genes in gut microbiota * Metabolic pathway of gut microbiota
Secondary Outcomes
- Antibiotic treatment(Pregnancy (12, 24, 37 weeks) and infants (born, 1 week, and 1, 3, 6, 12 months))