NCT06479941招募中不适用
Antibiotic Exposure During Pregnancy Affects Infant Gut Microbiota
适应症
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 450
- 试验地点
- 1
- 主要终点
- Infant gut microbiome
研究概览
简要总结
Based on a prospective birth cohort, the investigators will collect biological samples from participants including pregnant women and newborns, to measure the gut microbial diversity and metabolites of newborns. These results systematically evaluate the effects of antibiotic exposure on the structure and function of gut microbiota. The project can reveal the effects of antibiotic exposure on the growth and development of gut microbiota in early life.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 1 Day 至 12 Months（Child）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Pregnant woman
- •aged 20-40 years old
- •natural conception
- •single pregnancy
- •gestational age ≥36 weeks
- •normal Apgar score
- •no serious congenital diseases
排除标准
- 未提供
结局指标
主要结局
Infant gut microbiome
时间窗: Pregnancy (12, 24, 37 weeks) and infants (born, 1 week, and 1, 3, 6, 12 months)
* Diversity of gut microbiota * Abundance of antibiotic resistance genes in gut microbiota * Metabolic pathway of gut microbiota
次要结局
- Antibiotic treatment(Pregnancy (12, 24, 37 weeks) and infants (born, 1 week, and 1, 3, 6, 12 months))
研究者
xu xue
Vice Chief Physician
Peking University People's Hospital
研究点 (1)
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