Antibiotic Exposure During Pregnancy Affects Infant Gut Microbiota
- Conditions
- Antibiotics Affecting Newborn Gut Microbiota
- Registration Number
- NCT06479941
- Lead Sponsor
- Peking University People's Hospital
- Brief Summary
Based on a prospective birth cohort, the investigators will collect biological samples from participants including pregnant women and newborns, to measure the gut microbial diversity and metabolites of newborns. These results systematically evaluate the effects of antibiotic exposure on the structure and function of gut microbiota. The project can reveal the effects of antibiotic exposure on the growth and development of gut microbiota in early life.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 450
-
Pregnant woman
- aged 20-40 years old
- natural conception
- single pregnancy
- gestational age ≥36 weeks
-
Newborn
- normal Apgar score
- no serious congenital diseases
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Infant gut microbiome Pregnancy (12, 24, 37 weeks) and infants (born, 1 week, and 1, 3, 6, 12 months) * Diversity of gut microbiota
* Abundance of antibiotic resistance genes in gut microbiota
* Metabolic pathway of gut microbiota
- Secondary Outcome Measures
Name Time Method Antibiotic treatment Pregnancy (12, 24, 37 weeks) and infants (born, 1 week, and 1, 3, 6, 12 months) * Frequency of antibiotic treatment
* Kind and Dose of antibiotic;
* Duration of antibiotic use;
Trial Locations
- Locations (1)
The Peking University People's Hospital
🇨🇳Beijing, China
The Peking University People's Hospital🇨🇳Beijing, ChinaXue Xu, Dr.Contact010-88324385xuxue19877182@sina.com