Efficacy of left ventricular outflow tract velocity time integral (LVOT-VTI) and carotid artery velocity time integral (CA-VTI) as predictors of fluid responsiveness in patients with sepsis and septic shock
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- AIIMS
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Correlation of change in-left ventricular outflow tract velocity time integral (LVOT-VTI) and change in carotid artery velocity time integral (CA-VTI)
研究概览
简要总结
We did a prospective parallel group observational studyto assess efficacy of delta CA-VTI in predicting fluid responsiveness and itscorrelation with delta LVOT-VTI in critically patients on mechanicalventilation in sepsis, septic shock and those not in sepsis in a mixedmedical-surgical ICU.
To conclude, CA-VTI can be a useful dynamic variable toassess fluid responsiveness in critically ill patients on mechanicalventilation in sepsis and those not in sepsis and it correlates well withsimilar changes in LVOT-VTI and stroke volume in these patient population.However, in the more important subset of patient population with septic shock,usefulness of CA-VTI remains questionable. Further study with larger samplesize requires to be done to address this issue.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18.00 Year(s) 至 65.00 Year(s)（—）
- 性别
- All
入选标准
- •mechanically ventilated adult patients (aged between 18-65 years.
排除标准
- •BMI>30 Kg/m
- •Patients in whom PLR test cannot be performed (eg.raised ICP, intracranial space occupying lesions).
- •Patients with valvular heart diseases.
- •Patients with cardiomyopathy.
- •Patients having carotid artery stenosis.
- •Patients with pelvic and lower limb fractures.
结局指标
主要结局
Correlation of change in-left ventricular outflow tract velocity time integral (LVOT-VTI) and change in carotid artery velocity time integral (CA-VTI)
时间窗: at the time of echocardiography - i.e., at the time of recruitment
次要结局
- Correlation of delta LVOT VTI, delta SV and delta CA –VTI(And)