Incidence of Significant Mitral Regurgitation in Patients Presenting With Acute Heart Failure: Journey to Tertiary Centre
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Acute Heart Failure
- Sponsor
- Metanoic Health Ltd.
- Enrollment
- 500
- Locations
- 1
- Primary Endpoint
- Grade 3 and above mitral regurgitation in acute heart failure.
- Status
- Completed
- Last Updated
- 8 years ago
Overview
Brief Summary
The purpose of this study is to determine the prevalence of moderate-to-severe Mitral Regurgitation (MR) in acute Heart Failure (HF) patients requiring hospital admission.
Detailed Description
All patients admitted with symptoms of HF- (shortness of breath (SOB), peripheral oedema, palpitations and irregular heart beats) will be assessed by the Research Team. The level of BNP will be checked using a small device (i-STAT BNP) at the bedside. If results of the test suggest HF they will undergo special procedure called transthoracic echocardiography (TTE). TTE is an ultrasound scan of the heart which will enable the investigators' to grade severity of Mitral Regurgitation (MR) as well as strength of the heart muscle. The investigators will use bi-plane Simpton's method to calculate left ventricular (LV) ejection fraction (EF). Colour Doppler and PISA method will be used to quantify severity of MR or valve leak. Simultaneously there will be recording of heart sounds to find out if auscultation is reliable in identifying leaky valves.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Acute Heart Failure patients admitted to the Hospital
- •Elevated BNP level (\>30pg/ml)
Exclusion Criteria
- •Patients with BNP level (\< 30pg/ml)
Outcomes
Primary Outcomes
Grade 3 and above mitral regurgitation in acute heart failure.
Time Frame: 12 months
TTE Grading is done on colour Doppler and proximal isovelocity surface area (PISA) method.
Secondary Outcomes
- Establish correlation between BNP level and severity of MR in acute HF(12 months)
- The validity of Hospital Episode Statistics (HES) data against prevalence of grade 3-4 MR in the study.(12 month)