Physical Exercise in Hypertension, Randomised Clinical Trial
- Conditions
- Hypertension
- Registration Number
- NCT00218972
- Lead Sponsor
- Norwegian University of Science and Technology
- Brief Summary
Endurance training has a documented effect on hypertension. However, only low to moderate training intensity has so far been studied. High aerobic intensity should, from physiological considerations, prove more effective in also reducing high blood pressure. The present study is a randomised comparison of high versus moderate intensity versus training in groups, and general advice on 24 hour blood pressure in hypertensives. The training period is 12 weeks, with follow-up after 1 year. Maximum oxygen uptake, quality of life, left ventricular function and blood vessel reactivity are also measured.
- Detailed Description
Endurance training has documented effect on blood pressure in hypertension. However, only low to moderate training intensity has so far been studied. Higher aerobic intensity based on individual measurements of maximum oxygen uptake is more efficient in increasing oxygen uptake, and might prove more effective in lowering blood pressure. Group training, on the other hand is not individualised, but less personnel required and may prove more cost effective. Endurance training is shown to improve both systolic and diastolic left ventricular function, as well as endothelial function. Both can be measured non-invasively by ultrasound.
The study is an open, randomised study with four arms, comparing:
* High aerobic intensity interval training
* Moderate aerobic intensity training
* Group training
* Controls receiving standard advice on lifestyle and training
Training effect is measured by Max. Oxygen uptake, blood pressure by continuous 24 hour ambulatory measurement, Left ventricular function by echo Doppler and endothelial function by flow mediated vasodilation by ultrasound.
The effect of exercise on blood pressure is dependent on continued training. All patients will be followed up after one year.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 88
- Essential hypertension grade 1 - 2 without medical treatment
- End organ damage
- Two or more cardiovascular risk factors
- Diabetes
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method 24 hour blood pressure 12 weeks
- Secondary Outcome Measures
Name Time Method Maximum oxygen uptake 12 weeks Endothelial function 12 weeks Echocardiographic left ventricular function 12 weeks Quality of life 12 weeks
Trial Locations
- Locations (1)
Norwegian University of Science and Technology
🇳🇴Trondheim, Norway
Norwegian University of Science and Technology🇳🇴Trondheim, Norway