NCT01715428已完成不适用
Effects of Liraglutide on Cardio-Metabolic Risk Markers
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 300
- 试验地点
- 1
- 主要终点
- carotid intima-media thickness
研究概览
简要总结
Incretin-based therapies have shown significant effects beyond those on glucose metabolism. We aim in the present study to evaluate the effects of liraglutide on several cardio-metabolic risk markers.
详细描述
In details, we will evaluate the effects of liraglutide on carotid-intima media thickness, oxidative stress, ghrelin, heat shock proteins and lipoproteins.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients with a diagnosis of type-2 diabetes
排除标准
- •severe hepatic or renal diseases
结局指标
主要结局
carotid intima-media thickness
时间窗: every four months for a total period of 2 years
carotid intima-media thickness will be assessed by doppler ultrasonography
次要结局
- changes in plasma ghrelin concentrations and heat-shock proteins(after 2 months of therapy)
- changes in oxidative stress markers(after 2 months of therapy)
- changes in atherogenic lipoproteins(after 2 and after 4 months of therapy)
研究者
Manfredi Rizzo
Assistant Professor
University of Palermo
研究点 (1)
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