Parasympathetic Augmentation Via Respiratory Training for Patients With Systolic Heart Failure

Not Applicable

• Conditions: Diastolic Heart Failure

• Registration Number: NCT05223751
• Lead Sponsor: Lancaster General Hospital

Brief Summary

This is a prospective, randomized, controlled clinical trial in which participants with NYHA class II or III and symptomatic Heart Failure with reduced Ejection Fraction (HFrEF) (Ejection Fraction (EF) ≤ 45%) will be assigned to one of two treatment groups: standard of care or breathing therapy.

Detailed Description

To evaluate the effect of breathing training on the 6-minute walk test in a population of heart failure patients.

Enrollment/Baseline Visit During the enrollment visit, the participant will meet with the clinical research coordinator (CRC) to review any final questions regarding the study and the informed consent form will be signed. The enrollment visit must occur within one month of screening. Once the informed consent is signed, the following procedures will occur.

* Randomization: Participants will be randomized using REDCap in a 2:1 blocking method into the intervention group (breathing therapy) or the control (standard of care).

* N-terminal (NT)-pro hormone BNP (NT-proBNP): If an NT-proBNP was collected as standard of care within 3 months of enrollment, this can be used for study purposes and compared to the 6 month NT-proBNP.

* New York Heart Association Class: If the NYHA class is completed as standard of care within 3 months of enrollment, this can be used for study proposes.

* Kansas City Cardiomyopathy Questionnaire (KCCQ)

* Respiratory Rate

* Peak Expiratory Flow

* 6-minute walk test

* Orientation to the Heart Rate Variability 4 (HRV4) Training application: This will include downloading, creating an account for, and training the participant on the application.

The Intervention Group will also receiving training on the Meo Health breathing therapy, which will include:

* Being shown the Meo Health Breathing Therapy On-Boarding video

* Orientation to breathing application: Participants will be assisted in downloading and custom setting the Breathe application.

* Zoom Within one month of the baseline visit, participants in the intervention group will have a one-on-one training session with the Meo Health breathing coach. This will mark the beginning of their breathing therapy intervention.

3 Month Visit The 3 month visit will occur 3 months (± 14 days) from the one-on-one training session for participants in the intervention group . The participant will only meet with the CRC at the 3 month visit and all assessments will be completed by the CRC.

* NYHA class

* KCCQ

* Respiratory Rate

* Peak Expiratory Flow

* 6-minute walk test

* Assess compliance from HRV4 Training application questions

* Assess any possible adverse events

6 Month/Final Visit The 6 month visit will occur 6 months (± 14 days) from the one-on-one training session for participants in the intervention group. The participant will meet with the CRC at the 6 month visit, any assessments not completed as Standard of Care (SOC), will be completed by the CRC.

* NT-proBNP: If an NT-proBNP is ordered as standard of care for the participant, this can be used for study purposes and compared to the baseline NT-proBNP.

* NYHA class: If the NYHA class is completed as standard of care, this can be used for study purposes and compared to the baseline and 3 month values.

* KCCQ

* Respiratory Rate

* Peak Expiratory Flow

* 6-minute walk test

* Assess any possible adverse events

9 Month Structured Telephone Survey The 9 month structured telephone interview will take place for all participants who receive breathing training from Meo Health. Participants will be called by a study team member who will facilitate a short (3-5 minute) telephone survey about adherence and changes in health outcomes as a result of participation in the trial. (See appendix 15.4). The study team member will record all answers into REDCap. Upon completion of the survey, participants will be closed out of the study. If a study team member is unable to get in contact with a participant after two attempts, their status will be marked as "closed to follow-up" and they won't be interviewed.

Study Timeline

• Study First Submitted: 2022-01-25
• Study First Submitted QC: 2022-01-25
• Study First Posted: 2022-02-04
• Study Start: 2022-02-07
• Status Verified: 2024-02
• Last Update Submitted: 2024-02-26
• Last Update Posted: 2024-02-28
• Primary Completion: 2025-02-15
• Study Completion: 2025-02-15

Recruitment & Eligibility

• Status: ENROLLING_BY_INVITATION
• Sex: All
• Target Recruitment: 114

Inclusion Criteria

1. 18 years or older
2. Signed informed consent
3. NYHA class II-III heart failure
4. EF ≤ 45% (echo within 1 year of enrollment)
5. At least 30 days of stable medical regimen (no new neurohormonal blockade or Sodium-glucose co-transporter 2 inhibitors (SGLT2i). Dose adjustments allowed)
6. Likely to be compliant with breath training as assessed by the provider
7. Availability of a "smart" phone and internet access
8. Established care at Lancaster General Health Penn Medicine

Exclusion Criteria

1. Cardiac resynchronization therapy (CRT) within 6 months
2. Severe Chronic obstructive pulmonary disease (COPD)
3. History of diaphragm paralysis
4. Unable or unwilling to complete respiratory training protocol
5. Decompensated or American College of Cardiology (ACC) Stage D Heart Failure (HF)
6. Prior or planned chest/abdominal or nasal/facial surgery within 6 months
7. Neuromuscular disease which impairs respiration
8. Diagnosed cognitive impairment (unable to participate in training)
9. Untreated obstructive severe sleep apnea (AHI > 30)
10. Severe valvular heart disease
11. Uncontrolled atrial fibrillation (Ave Heart Rate (HR) > 100 bpm)
12. Orthopedic or other limitations which impair the 6-minute walk test

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Change from baseline to 6 months for the 6-minute walk test (6MWT)	Baseline, 6 months	Distance (m) covered in six minutes from baseline to 6 months

Secondary Outcome Measures

Name	Time	Method
Pulmonary parameters: Peak expiratory flow	Baseline, 3 months, 6 months	Change in peak expiratory flow spirometry
Kansas City Cardiomyopathy Questionnaire 12 (KCCQ12) quality of life score	Baseline, 3 months, 6 months	Change in Kansas City Cardiomyopathy Questionnaire 12 - Quality of Life (KCCQ12-QL) score; KCCQ12-QL score corresponds to Questions 6 and 7. Responses are coded as follows: Question 6 Response It has extremely limited my enjoyment of life = 1 It has limited my enjoyment of life quite a bit = 2 It has moderately limited my enjoyment of life = 3 It has slightly limited my enjoyment of life = 4 It has not limited my enjoyment of life at all = 5; Question 7 Response Not at all satisfied = 1 Mostly dissatisfied = 2 Somewhat satisfied = 3 Mostly satisfied = 4 Completely satisfied = 5; If responses to both questions are missing, no score is computed. Otherwise, the score is calculated by taking the average of the non-missing responses and rescaling to 0-100, as follows: KCCQ12-QL = 100\*\[(average of Questions 6 and 7) - 1\]/4; Scores are scaled 0-100, where 0 denotes the lowest reportable health status and 100 the highest.
New York Heart Association (NYHA) Class (graded I-IV) Proportion Improved 1 Class	Baseline, 6 months	Proportion of subjects that decreased 1 NYHA class.; NYHA Classification - The Stages of Heart Failure: Class I - Cardiac disease, but no symptoms and no limitation in ordinary physical activity.; Class II - Mild symptoms and slight limitation during ordinary activity. Class III - Significant limitation in activity due to symptoms. Comfortable only at rest.; Class IV - Severe limitations. Symptoms even while at rest. No NYHA class listed or unable to determine.

Trial Locations

Locations (1)

Lancaster General Hospital; 🇺🇸 Lancaster, Pennsylvania, United States