Prothrombin complex concentrate in the reduction of blood loss during orthotopic liver transplantation.

Phase 4

Completed

Conditions: Bleeding
hemorrhage
10064477

Registration Number: NL-OMON40112

Lead Sponsor: niversitair Medisch Centrum Groningen

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 60

Inclusion Criteria

- At least 18 years
- Eligible for OLT
- Signed informed consent

Exclusion Criteria

- Split liver transplantation
- Heterotopic liver transplantation
- Scheduled multiorgan transplantation
- Scheduled living related-donor transplantation
- Documented congenital coagulation disorders
- Documenten history or presence of arterial or venous thrombosis
- Treatment with coumarin
-Acute hepatic failure without previous known history of hepatic disease
- Coronary artery disease
- Documented history of thrombophilia
- Hypercoagulability assessed by preoperative thromboelastography

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>1) Number of RBC (red blood cell) units transfused during and immediatly after<br /><br>liver transplantation.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>1)The number of units of fresh-frozen plasma<br /><br>2) Units of platelet concentrate<br /><br>3) Fibrinogen concentrate administration<br /><br>4) Calculated Hb loss<br /><br>5) Antifibrinolytic drugs<br /><br>6) Crystalloids or colloids administered, the number of units of allogeneic and<br /><br>autologous (if used)<br /><br>7) Other escape medication used<br /><br>8) Amount of blood loss and amount of ascites loss</p><br>