Effects of Plant Based Lipids on Glucose Regulation and Cognitive Variables
- Conditions
- ObesityDiabete Type 2
- Interventions
- Dietary Supplement: lipids
- Registration Number
- NCT05276128
- Lead Sponsor
- Lund University
- Brief Summary
The overall goal is to increase the knowledge that can be used for the development of food products with anti-diabetic properties, with the purpose to facilitate healthier food choices for people. More specifically the primary purpose of this project is to evaluate effects in healthy humans on acute postprandial glucose regulation of plant based lipids. Due to the tight connection between cardiometabolic health and cognitive functions, a secondary issue is to investigate effects of test foods on cognitive test variables and mood parameters.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 17
- Apparently healthy subjects
- Between 20 and 40 years old
- Body mass index between 19-28 kg / m2),
- Consuming a non-vegetarian diet generally in line with the Nordic nutrition recommendations.
- Fasting blood glucose concentration >6.1 mmol/L
- Known metabolic or gastrointestinal disorder (eg diabetes, high cholesterol, high blood pressure, IBS), or other disease that may affect the study results.
- Regular medication, except for long-term and stable medication for the lack or reduced production of thyroid hormone (eg Levaxin).
- Antibiotics or probiotics for at least four weeks before the start of the study,
- The use of tobacco products
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Arm && Interventions
Group Intervention Description WWB Reference lipids White wheat bread (WWB) without lipid supplements. The effects of this high glycaemic product on postprandial glucose and insulin responses are well studied. WWB 10g active lipids lipids WWB supplemented with 10g active lipids, and 5 g control lipids WWB 5g active lipids lipids WWB supplemented with 5 g active lipids, and 10 g control lipids WWB 15g active lipids lipids WWB supplemented with 15g active lipids, and 0 g control lipids WWB 15 g control lipids lipids WWB supplemented with 15g control lipids
- Primary Outcome Measures
Name Time Method glucose tolerance 3 hours. Fasting (time =0), 15 minutes, 30 minutes, 45 minutes, 60 minutes, 90 minutes, 120 minutes, 150 minutes, 180 minutes Postprandial blood glucose responses
- Secondary Outcome Measures
Name Time Method Insulin responses 3 hours. Fasting (time =0 minutes), 30 minutes, 45 minutes, 60 minutes, 90 minutes, 120 minutes, 150 minutes, 180 minutes Postprandial insulin responses
Mood variables 60 minutes after start of test product, after 120 minutes and after 180 minutes Registration of subjective mood ratings (valence and activity) on 0-100 mm Visual Analogue Scales (VAS) at fasting and thereafter every hour until 180 min. Extremes of the sensations of the variables is at the two ends of the scales, i.e. 0 mm relates to the extrem of low senations sensations and 100 mm correspond to the highest sensation of the variables.
Appetite sensations 3 hours. Fasting (time =0), 15 minutes, 30 minutes, 45 minutes, 60 minutes, 90 minutes, 120 minutes, 150 minutes, 180 minutes Subjective sensations of hunger, satiety, and desire to eat are registered on 0-100 mm VAS scales. Extremes of the sensations of the variables is at the two ends of the scales, i.e. 0 mm relates to the extrem of low senations sensations and 100 mm correspond to the highest sensation of the variables.
Trial Locations
- Locations (2)
Anne Nilsson
🇸🇪Lund, Välj..., Sweden
The Human Trial Facility, Food Technology engineering and Nutrition, Lund University
🇸🇪Lund, Välj..., Sweden