Novel α2-Antiplasmin Inactivation for Lysis of Intravascular Thrombi (NAIL-IT) Trial

Phase 2

Recruiting

• Conditions: Pulmonary Embolism
• Interventions: Drug: TS23; Drug: Placebo

• Registration Number: NCT05408546
• Lead Sponsor: Translational Sciences, Inc.

Brief Summary

Phase II trial of TS23

Detailed Description

Evaluation of safety and thrombolytic effect of ascending doses of TS23 in subjects with intermediate-risk (sub-massive) acute pulmonary embolism (PE)

Study Timeline

• Study First Submitted: 2022-05-21
• Study First Submitted QC: 2022-06-03
• Study First Posted: 2022-06-07
• Study Start: 2023-05-24
• Status Verified: 2023-07
• Last Update Submitted: 2023-07-08
• Last Update Posted: 2023-07-11
• Primary Completion: 2024-07
• Study Completion: 2024-09

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 32

Inclusion Criteria

1. Male or female subjects, age >18 years;
2. PE involving a segmental or more proximal pulmonary artery confirmed by CTPA scan and with an onset of symptoms not more than 5 days prior to diagnosis;
3. Subject is hemodynamically stable with a systolic blood pressure (SBP) >90 mm Hg;
4. Subject has evidence of RV dysfunction as indicated by a right ventricular-to-left ventricular (RV/LV) diameter ratio > 0.9 on CTPA scan (measuring the minor axis of the right and left ventricle in the transverse plane), prior to the initiation of study drug administration.

Exclusion Criteria

1. Subjects for whom thrombolytic therapy or thrombectomy is planned; or subjects with history of administration of thrombolytic agents within the previous 4 days;

2. Subjects receiving ≥ 48 hours of therapeutic doses of heparin or low molecular weight heparin (LMWH) or other anticoagulant therapy immediately prior to randomization;

3. Subjects with contraindications to SOC therapies such as unfractionated heparin or LMWH or oral anticoagulant, or any of the excipients (including study drug excipients);

4. Subjects who are considered at very high risk of bleeding:

   1. Known coagulation disorder with history of pathologic bleeding tendencies

   2. Subjects with prior intracranial hemorrhage, known arteriovenous malformation or aneurysm of the brain, or evidence of active bleeding;

   3. Subjects with a history of major surgery, clinically significant head trauma (in the opinion of the Principal Investigator), or stroke in the past 3 months prior to randomization;

   4. Subjects with uncontrolled hypertension defined as SBP ≥180 mm Hg and/or diastolic BP (DBP)

      ≥110 mm Hg at randomization

   5. Subjects requiring concomitant dual antiplatelet therapy

5. Subjects with Creatinine Clearance (CrCL) < 30 mL/min or serum creatinine ≥ 2.5 mg/dL;

6. Subjects with hemoglobin < 8.0 g/dL;

7. Subjects with a platelet count < 100,000/µL;

8. Subjects with acute or persistent hepatitis or diagnosed active liver disease or with elevation of liver enzymes: Alanine transaminase (ALT) or aspartate transaminase (AST) ≥ 3 x upper limit of normal (ULN);

9. Subjects with known history of testing positive for Hepatitis B antigen or Hepatitis C antibody;

10. Subjects with known history of testing positive for the human immunodeficiency virus (HIV);

11. Subjects with life-expectancy < 6 months;

12. Female subjects of child bearing potential with a positive pregnancy test or who are lactating, or unwilling to use highly effective methods of contraception. Highly effective methods of birth control include combination hormonal therapy (estrogen and progresterone), contraceptives administered orally, intravaginally or transdermally, progesterone-only contraceptives administered orally, by injection or implantation, use of an intrauterine device (IUD), intrauterine hormone- releasing system (IUS), bilateral tubal occlusion, partner vasectomy or sexual abstinence;

13. Subjects currently participating in another investigational study or who have participated in an investigational drug study within 30 days (or longer depending on the half-life of the investigational drug; should allow at least five half-life of the investigational drug) prior to randomization.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Intermediate dose TS23	TS23	TS23 medium dose + SOC anticoagulation
Placebo	Placebo	Placebo + standard of care (SOC) anticoagulation
Higher dose TS23	TS23	TS23 highest dose + SOC anticoagulation
Low dose TS23	TS23	TS23 low dose + SOC anticoagulation

Primary Outcome Measures

Name	Time	Method
Safety- Bleeding	within 7 days of treatment	Frequency of major or clinically significant bleeding
RV/LV	48 hours after treatment	Ratio of the right to left ventricle dimensions on CT perfusion angiogram (CTPA)

Secondary Outcome Measures

Name	Time	Method
Thrombus dissolution	48 hours after treatment	Change in modified Miller Score

Trial Locations

Locations (1)

Cedars Sinai Medical Center; 🇺🇸 Los Angeles, California, United States