Association between time to initiation of norepinephrine infusion and mortality outcome in patients with septic shock
Completed
- Conditions
- septic shock patient requiring norepinephrineMortality, Septic shock, initiation norepinephrine, Time, Norepinephrine
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 138
Inclusion Criteria
Adult patients aged 18 years or older diagnosed with septic shock were included. The septic shock was defined by patients with suspected infection (documented or probable) who had Ramathibodi Early Warning Score (REWS) equal or more than 2, includingMAP less than 65 mm Hg and required norepinephrine infusion within 24 hours following the hypotensive event
Exclusion Criteria
patients who had a hemorrhagic shock, cardiogenic shock, end-of-life care, and patients who were delayed antibiotic more than 1 hour, received other vasopressor drugs prior to norepinephrine, changed in diagnosis within 24 hours, pregnancy, and were referred to another hospital. Patients who signed to decline or discontinue the study were also excluded.
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 28-day all cause mortality 28 day after admission discharge summary
- Secondary Outcome Measures
Name Time Method ventilator free day 28 day after admission discharge summary outcome record,The time to achieve MAP 65 mm Hg 28 day after admission discharge summary outcome record,net fluid balance 24, 48, 72 hour discharge summary outcome record,lactate clearance 24, 48, 72 hour discharge summary record outcome