Simultaneous CBCT Acquisition During Arc Radiotherapy

Not Applicable

• Conditions: Prostate Cancer; Lung Cancer
• Interventions: Radiation: Cone Beam Computed Tomography

• Registration Number: NCT02123888
• Lead Sponsor: Sally Falk

Brief Summary

The cone beam image is a part of the radiotherapy treatment machine and uses lower energy xrays as the head of the radiotherapy machine moves around the patient in a circle. This takes pictures that give 3-dimensional information, somewhat like a CT scan. These images are better at showing the position of the tumour and surrounding soft tissues than the standard xrays that were previously used. Cone Beam Imaging Technology is not new and has been used regularly at The Christie for many years. The standard cone beam scan is taken before the actual radiotherapy treatment or after the treatment has been delivered.

Volumetric Modulated Arc Therapy (VMAT or Arc Radiotherapy) is a novel method of delivering radiotherapy that involves the continuous movement of the radiotherapy treatment machine head around the patient and MLC during radiation. Arc radiotherapy has been clinically implemented at The Christie for prostate radiotherapy treatments and work is in progress for implementation in lung radiotherapy. The continuous gantry rotation inherent to VMAT delivery makes this simultaneous imaging possible, although there are concerns associated with the impact that this may have on patient dose and image quality.

The aim of this research is to assess whether the image quality of cone beam scans taken during treatment are as good as standard cone beam scans taken before or after treatment used to determine the accuracy of patient position and the tumour coverage by radiotherapy.

Detailed Description

Not available

Study Timeline

• Study Start: 2011-06
• Study First Submitted: 2014-04-22
• Study First Submitted QC: 2014-04-24
• Study First Posted: 2014-04-28
• Status Verified: 2015-02
• Last Update Submitted: 2015-02-06
• Last Update Posted: 2015-02-09
• Primary Completion: 2015-12
• Study Completion: 2015-12

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 75

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Cone Beam Computed Tomography	Cone Beam Computed Tomography	Simultaneous Cone Beam Computed Tomography acquisition during arc radiotherapy.

Primary Outcome Measures

Name	Time	Method
Equivalence of image quality	12 months	To show equivalence of image quality from simultaneous CBCT acquisition during delivery of arc radiotherapy with that obtained from conventional CBCT acquisition in lung and prostate patients, as assessed by user-questionnaires.

Secondary Outcome Measures

Name	Time	Method
Quantify inter-observer variation	12 months	To quantify inter-observer variation in delineation of specific structures on CBCT scans.
Quantify impact on treatment times.	12 months	To quantify the impact of simultaneous CBCT scans on treatment times.

Trial Locations

Locations (1)

The Christie NHS Foundation Trust; 🇬🇧 Manchester, Greater Manchester, United Kingdom