Effects of Green Coffee Extract Supplementation on Adropin, Irisin, Vaspine,Systemic Inflammation and Oxidative Stress in Breast Cancer Survivors

Not Applicable

• Conditions: Breast Cancer Survivors
• Interventions: Dietary Supplement: green coffee; Other: control

• Registration Number: NCT03395561
• Lead Sponsor: National Nutrition and Food Technology Institute

Brief Summary

To study the effects of green coffee supplement on adropin, irisin, vaspine, systemic inflammation and oxidative stress in breast cancer survivors.50 breast cancer survivors who their treatment is over and referred to follow breast cancer clinic with will be randomly allocated to receive placebos or 2 capsules green coffe for 12 weeks; both groups will be advised to adherence the investigators' diet and exercise program too. At the first and the end of the intervention, adropin, irisin, vaspine, systemic inflammation and oxidative stress will be assessed and compared between groups.

Detailed Description

Not available

Study Timeline

• Status Verified: 2017-12
• Study First Submitted: 2017-12-26
• Study First Submitted QC: 2018-01-03
• Last Update Submitted: 2018-01-03
• Study First Posted: 2018-01-10
• Last Update Posted: 2018-01-10
• Study Start: 2018-02-11
• Primary Completion: 2019-01-11
• Study Completion: 2019-10-11

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: Female
• Target Recruitment: 50

Inclusion Criteria

• Age of 18 to 70 years
• Body Mass Index (BMI) between 25-40 treatment is over

Exclusion Criteria

• Taking any kind of supplement for weight reduction
• pregnancy or lactation
• Professional athletes

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
green coffe	green coffee	2 capsuls of green coffe
control	control	2 capsuls

Primary Outcome Measures

Name	Time	Method
Interleukin 6	12 weeks	assessed by ELISA
Tumor necrosis factor alpha	12 weeks	assessed by ELISA

Secondary Outcome Measures

Name	Time	Method
body mass index	12 weeks	The body mass index (BMI) or Quetelet index is a value derived from the mass (weight) and height of an individual. The BMI is defined as the body mass divided by the square of the body height, and is universally expressed in units of kg/m2, resulting from mass in kilograms and height in metres.

Trial Locations

Locations (1)

National Nutrition and Food Technology Research Institute; 🇮🇷 Tehran, Iran, Islamic Republic of