Measurement of Respiratory Admittance for Pediatric Asthma Diagnosis
- Conditions
- Asthma
- Interventions
- Registration Number
- NCT02877537
- Lead Sponsor
- Central Hospital, Nancy, France
- Brief Summary
The purpose is to characterize the change of respiratory admittance induced by salbutamol inhalation in children and young adults. A variation threshold will be fixed to distinguish asthmatic and healthy subjects.
This project could allow a better identification of asthmatic individuals needing a treatment, a reduction of morbidity of asthma, a reduction of unnecessary treatments administered in individuals with respiratory but not asthmatic symptoms, a better comprehension of bronchial hyperreactivity and its role in asthmatic disease.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 177
Asthmatic children group:
- Several episodes of paroxysmal wheezes, spontaneous or after exercise, without bronchial-pulmonary infection
- Absence of bronchodilator taking during last 12 hours
- Absence of reported intolerance to adrenergic substances
- Parental authorization and consent of child to participate to the study
Control children group:
- Parental authorization and consent of child to participate to the study
Control adult group:
- Consent to participate to the study
Control children and adult groups:
- At least 2 episodes of wheezes during breathing
- Several wheezes, abnormal breathlessness, cough during physical exercise
- Asthma diagnosed by family doctor
- Administration of drugs to treat asthma
- Eczema or food allergy at inclusion
- Episode of cough for longer than 6 weeks, without bronchial infection
- Bronchitis, throat infection, rhino-pharyngitis during last 15 days
- Paleness or cyanosis with loss of consciousness when the child was a baby or during an exercise
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Asthma child Forced oscillation technique - Asthma child Plethysmography - Control adult Forced oscillation technique - Control adult Plethysmography - Control child Forced oscillation technique - Control child Plethysmography - Asthma child Salbutamol - Control adult Salbutamol - Control child Salbutamol -
- Primary Outcome Measures
Name Time Method Ventilatory mechanical impedance day 0 Measured with Forced oscillation technique. 2 measures at basal status at 10 min interval for reproducibility and after 10 min broncodilation with salbutamol
Thoracic gas volume day 0 Measured with Plethysmography.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
CHU de Nancy - Hôpital BRABOIS Enfants - Explorations fonctionnelles pédiatriques
🇫🇷Vandœuvre-lès-Nancy, France