NCT07568678招募中1 期
A Phase 1, Randomized, Placebo-Controlled, Double-Blind, Multiple- Dose Escalation Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of HMS1005 in Participants With Type 2 Diabetes
Hua Medicine Limited1 个研究点 分布在 1 个国家目标入组 40 人开始时间: 2025年12月4日最近更新:
适应症
干预措施
相关药物
试验速览
- 阶段
- 1 期
- 状态
- 招募中
- 发起方
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- Incidence of adverse events
研究概览
简要总结
The study is to assess the safety, pharmacokinetics, and pharmacodynamic profile of HMS1005 in patient with diabetes
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Sequential
- 主要目的
- Treatment
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Males or females, of any race, between 18 and 65 years of age, inclusive.
- •Body mass index between 18 and 38.0 kg/m2, inclusive.
- •Females will not be pregnant or lactating, and females of childbearing potential and males will agree to use contraception as detailed in Appendix
- •T2DM, as determined by the ADA Standard Care Diagnostic Criteria 2025, and
- •are drug naïve, treated with diet and exercise, or
- •have been on a stable dose of ≤2000 mg metformin for ≥1 month, and/or
- •have been on a stable dose of other antidiabetic medications for ≥90 days.
- •Except for findings consistent with T2DM, in good health, determined from medical history, 12-lead electrocardiogram (ECG), vital signs measurements, clinical laboratory evaluations, and physical examinations at screening and/or check in, as assessed by the Investigator (or designee).
- •Doses of antihypertensive and lipid-lowering therapies must be stable for 30 days prior to screening and remain unchanged during the study unless necessary to protect participant safety on an emergency basis (e.g., hypertensive crisis).
- •Glycated hemoglobin between 7.0% and 10.5%, inclusive.
- •Fasting plasma glucose between 126 and 240 mg/dL, inclusive. Testing may be repeated once, at the discretion of the Investigator (or designee).
- •Able to comprehend and willing to sign an ICF and to abide by the study restrictions.
排除标准
- •Type 1 diabetes mellitus, maturity onset diabetes of the young, or diabetes mellitus caused by damage to the pancreas or any other condition (eg, acromegaly or Cushing's syndrome).
- •Diabetic neuropathy, retinopathy, or nephropathy.
- •History of acute diabetic complications such as diabetic ketoacidosis, hyperglycemic hyperosmolar syndrome, lactic acidosis, or hyperosmolar nonketotic coma within the 6 months prior to screening, or chronic metabolic acidosis.
- •History of severe hypoglycemia, defined as severe cognitive impairment requiring external assistance for recovery within 3 months prior to dosing; or recurrent hypoglycemia (Level 2), defined as ≥2 episodes within 3 months prior to dosing; or ADA Level 3 hypoglycemia within 6 months prior to dosing.
- •Hypoglycemia unawareness or asymptomatic hypoglycemia.
- •Clinically significant history of liver disease (eg, hepatitis and cirrhosis) within 1 year prior to screening.
- •Clinically significant history of renal disease. Mild to moderate chronic kidney disease is permitted.
- •Clinically significant history of cardiovascular disease, particularly coronary artery disease, arrhythmias, atrial tachycardia, or congestive heart disease within 1 year prior to screening. Managed hypertension is permitted (defined as systolic blood pressure <160 mmHg and/or diastolic blood pressure <100 mmHg).
- •Clinically significant history of any central nervous system or psychiatric disease, including transient ischemic attack, stroke, seizure disorder, depression, or behavioral disturbances within 1 year prior to screening.
- •Clinically significant gastric emptying abnormality (eg, severe diabetic gastroparesis or gastric outlet obstruction) or have had gastric bypass surgery.
- •Clinically significant or unstable history of any hepatic, renal, hematological, pulmonary, cardiovascular, gastrointestinal, neurological, endocrine, or psychiatric disorder, as determined by the Investigator (or designee).
- •Known or active malignancy, except basal cell carcinoma and cutaneous squamous cell carcinoma.
- •Any hospital admission or major surgery within 90 days prior to screening.
- •History of significant hypersensitivity, intolerance, or allergy to any drug compound, food, or other substance, as determined by the Investigator (or designee).
- •Fasting C peptide < 0.81 ng/mL.
- •Alanine aminotransferase, aspartate aminotransferase, or gamma glutamyl transferase >2 × the upper limit of normal (ULN); or total bilirubin >1.5× ULN. Testing may be repeated once, at the discretion of the Investigator (or designee).
- •Uncontrolled hypertriglyceridemia > 500 mg/dL.
- •Estimated glomerular filtration rate ≤ 45 mL/minutes/1.73 m2, as calculated using the 2021 Chronic Kidney Disease Epidemiology equation.
- •Hemoglobin ≤120 g/L (male) or ≤110 g/L (female).
- •QT interval corrected for heart rate using Fridericia's method > 450 msec.
- •Positive hepatitis B surface antigen, hepatitis C antibody, human immunodeficiency (HIV 1 and HIV 2) antibodies and p24 antigen.
- •Positive pregnancy test.
- •Use of insulin, sulfonylureas, GLP-1 agonists, DPP-4 inhibitors, SGLT2 inhibitor and glinides (eg, repaglinide and nateglinide).
- •Use of any strong or moderate cytochrome P450 (CYP) 3A4 inducers within 28 days prior to dosing or any strong or moderate CYP3A4 inhibitors within 7 days or 5 half-lives, whichever is longer, prior to dosing (Appendix 5).
- •Use of any P glycoprotein inducers within 14 days prior to dosing or any P glycoprotein inhibitors within 5 days or 5 half-lives, whichever is longer, prior to dosing (Appendix 6).
- •Use of any carboxylesterase 2 inhibitors within 5 days or 5 half-lives, whichever is longer, prior to dosing (Appendix 7).
- •Participation in a clinical study involving administration of an investigational drug (new chemical entity) in the past 30 days.
- •Positive alcohol test result, or positive urine drug screen (confirmed by repeat) at screening or check in.
- •Current drug abuse, defined as the use of any illegal substance or misuse or excessive used of over the counter or prescription drugs; or current alcohol abuse, defined as the inability to stop or control alcohol use, despite adverse social or health consequences.
- •Consumption of alcohol, or caffeine containing foods or beverages within 48 hours, or foods and beverages containing grapefruit or Seville oranges within 7 days prior to check in.
- •Use of tobacco or nicotine containing products within 1 month prior to screening.
- •Receipt or donation of > 1 unit (approximately 450 mL) of blood products within 3 months prior to screening.
- •Poor peripheral venous access.
- •Participants who, in the opinion of the Investigator (or designee), should not participate in this study.
研究组 & 干预措施
246 mg HMS1005 (1 x 246 mg tablet) or placebo
Experimental
active vs placebo: 6 to 2
干预措施: Matching placebo (Drug)
123 mg HMS1005 (1 x 123 mg tablet) and matching placebo
Experimental
active vs placebo: 6 to 2
干预措施: HMS1005 (Drug)
123 mg HMS1005 (1 x 123 mg tablet) and matching placebo
Experimental
active vs placebo: 6 to 2
干预措施: Matching placebo (Drug)
184.5 mg HMS1005 (1 x 184.5 mg tablet) and matching placebo
Experimental
active vs placebo: 6 to 2
干预措施: HMS1005 (Drug)
184.5 mg HMS1005 (1 x 184.5 mg tablet) and matching placebo
Experimental
active vs placebo: 6 to 2
干预措施: Matching placebo (Drug)
369 mg HMS1005 (2 x 184.5 mg tablet) and matching placebo
Experimental
active vs placebo: 6 to 2
干预措施: HMS1005 (Drug)
369 mg HMS1005 (2 x 184.5 mg tablet) and matching placebo
Experimental
active vs placebo: 6 to 2
干预措施: Matching placebo (Drug)
492 mg HMS1005 (2 x 246 mg tablet) and matching placebo
Experimental
active vs placebo: 6 to 2
干预措施: HMS1005 (Drug)
492 mg HMS1005 (2 x 246 mg tablet) and matching placebo
Experimental
active vs placebo: 6 to 2
干预措施: Matching placebo (Drug)
246 mg HMS1005 (1 x 246 mg tablet) or placebo
Experimental
active vs placebo: 6 to 2
干预措施: HMS1005 (Drug)
结局指标
主要结局
Incidence of adverse events
时间窗: From enrollment to the end of treatment at Day 19
incidence and severity of adverse events from Day1 to Day 19
Area under the plasma concentration versus time curve (AUC)
时间窗: Single-dose: Day 1-3 steady-state: Day 14-17
Measure area under the concentration-time curve from time 0 to 72 hours postdose of HM-002-1005 in plasma after single-dose and at steady-state
Maximum observed concentration (Cmax)
时间窗: Single-dose: Day 1-3 steady-state: Day 14-17
Cmax of HM-002-1005 in plasma after single and multiple dose
Time of the maximum observed concentration (Tmax)
时间窗: Single-dose: Day 1-3 steady-state: Day 14-17
Time of the maximum observed concentration (Tmax) of HM-002-1005
Apparent terminal elimination half life (t1/2)
时间窗: Single-dose: Day 1-3 steady-state: Day 14-17
t1/2 of HM-002-1005 in plasma
次要结局
- Glucose concentration(Day -1 and 14)
- Glucose time in range (70-180 mg/dL) %(From Day -10 (baseline) to Day 17)
研究者
研究点 (1)
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