EUCTR2012-001131-31-DKActive, not recruitingPhase 1
Effekts of nebivolol on the nitric oxide system in patients with essentiel hypertension - NEBI
Conditions
Drugs
Trial Snapshot
- Phase
- Phase 1
- Status
- Active, not recruiting
- Enrollment
- 25
Study Overview
Brief Summary
No summary available.
Study Design
- Study Type
- Interventional clinical trial of medicinal product
Eligibility Criteria
- Sex
- All
Inclusion Criteria
- •Men and women
- •Age 40-70 years
- •Ambulatory blood pressure > 135 mmHg systolic and/or 85 mmHg diastolic in daytime during amlodipine treatment with either 5 or 10 mg
- •Informed consent
- •Fertiel women must take contraception
- •Are the trial subjects under 18? no
- •Number of subjects for this age range:
- •F.1.2 Adults (18-64 years) yes
- •F.1.2.1 Number of subjects for this age range 25
- •F.1.3 Elderly (>=65 years) yes
- •F.1.3.1 Number of subjects for this age range 25
Exclusion Criteria
- •Diabetes mellitus
- •eGFR < 30
- •Albuminuria > 1,5 g/L
- •Renografi indicating sekundary hypertension
- •clinical signs of pheoocromocyta eller abnormal p-metanefrin.
- •Clinical important signs of lung, heart, liver or thyroid disease l
- •Clinical important abnormalities in screening blood samples and ECG
- •Clinical important hypokalimia
- •Clinical important abnormalities in plasma calcium
- •Neplastic diseases
- •Alcoholabuse
- •Drug or medical abuse
- •Pregnancy or nursing
- •Intolerans towards nebivolol
- •Bloddonationwithin a month
- •Uacceptable side effects to amlodipine
- •Ambulatory BP above 170/105 mmHg on hightest dose amlodipine 10mg)
Investigators
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