Effects of Intramural Fibroids on IVF Outcome
- Conditions
- Infertility, FemaleAssisted Reproduction
- Interventions
- Drug: GonadotropinsProcedure: Ovum pick upProcedure: Embryo transfer
- Registration Number
- NCT03904355
- Lead Sponsor
- Cairo University
- Brief Summary
A cohort study involving 200 women candidate for IVF / ICSI cycles . The participants will be assessed through full history-taking with special consideration to age and the duration, type, and cause of infertility. The medical examination included general, abdominal, and vaginal examinations. Finally, an ultrasonography examination was performed to check for the presence of three or more preantral follicles and to exclude ovarian cysts.
On day 3 of a natural cycle, a baseline levels of FSH, luteinizing hormone (LH),
, estradiol and anti-Müllerian hormone (AMH).Ovarian stimulation was performed using a long, antagonist, or short protocol. They were assigned to one of the 2 groups according to having an intramural myoma not indenting the cavity or not. All will be followed up by transvaginal ultrasonography . When two or more follicles had reached a mean diameter of 18 mm, oocyte maturation was triggered by intramuscular administration of hCG. Embryo transfer will be done at day 2, 3 or 5 according to the circumstances.
- Detailed Description
A cohort study involving 200 women candidate for IVF / ICSI cycles . The participants will be assessed through full history-taking with special consideration to age and the duration, type, and cause of infertility. The medical examination included general, abdominal, and vaginal examinations. Finally, an ultrasonography examination was performed to check for the presence of three or more preantral follicles and to exclude ovarian cysts.
On day 3 of a natural cycle, a baseline levels of FSH, luteinizing hormone (LH),
, estradiol and anti-Müllerian hormone (AMH).Ovarian stimulation was performed using a long, antagonist, or short protocol. They were assigned to one of the 2 groups according to having an intramural myoma not indenting the cavity or not. All will be followed up by transvaginal ultrasonography . When two or more follicles had reached a mean diameter of 18 mm, oocyte maturation was triggered by intramuscular administration of hCG. Embryo transfer will be done at day 2, 3 or 5 according to the circumstances.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- Female
- Target Recruitment
- 200
- age younger than 40 years
- FSH) less than 10 IU/L
- serum prolactin level normal
- uterine cavity abnormality was excluded by hysteroscopy or hysterosalpingography.
- abnormal endocrine function (e.g. abnormal thyroid or adrenal function)
- ovarian cysts,
- hydrosalpinx
- endometrial polyps
- male partner with azoospermia
- ICSI performed for preimplantation genetic diagnosis.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Fiboroid group Gonadotropins Women with intramural myoma no reaching the cavity Fiboroid group Ovum pick up Women with intramural myoma no reaching the cavity Fiboroid group Embryo transfer Women with intramural myoma no reaching the cavity Non fibroid group Gonadotropins Women without myomas Non fibroid group Ovum pick up Women without myomas Non fibroid group Embryo transfer Women without myomas Fiboroid group human chorionic gonadotropin Women with intramural myoma no reaching the cavity Non fibroid group human chorionic gonadotropin Women without myomas
- Primary Outcome Measures
Name Time Method clinical pregnancy rate 4 weeks after embryo transfer appearance of one or more intrauterine gestational sac
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Kasr Alainy medical school
🇪🇬Cairo, Egypt