The advantage of lycopene capsule over cleaning and polishing in smokers having gum problems
- Conditions
- Chronic periodontitis,
- Registration Number
- CTRI/2020/10/028670
- Lead Sponsor
- Justina David Joy
- Brief Summary
This study is being conducted to assess the salivary total antioxidant capacity in smokers with periodontitis before and after treatment with systemic administration of lycopene. In normal physiology there is a dynamic equilibrium between the reactive oxygen species (ROS) and antioxidants which is shifted if there is a decrease in the antioxidant release or increase in ROS leading to oxidative stress. ROS if produced in high amounts is capable enough to cause periodontal tissue destruction by acting directly or indirectly on tissue and cause damage which is neutralized by the antioxidants. Thus antioxidants play a major role in the protection of normal health of periodontium. Smoking plays an important role in the pathogenesis of periodontal diseases by increasing the oxidative stress, causing imbalance between oxidative stress and antioxidant capacity and dysregulation of innate and adaptive immune system. Lycopene are the carotenoid which are responsible for the yellow , red and orange pigments and are synthesized in plants and have been linked to oxidation preventing mechanisms. The developing degenerative diseases such as asthma, cancer, cardiovascular diseases, stroke, arthritis, hepatitis and also periodontitis caused by free radicals has shown a reduction with the consumption of lycopene. It is considered as the most effective antioxidant agent because of its uncommon feature of binding to chemical species that react to oxygen. Studies have also shown that lycopene is a promising treatment modality as an adjunct to scaling and root planing in chronic periodontitis patients.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Not Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 30
- The subjects should be systemically healthy.
- Age group : 25 to 64 years -Probing depth ≥ 4mm -Minimum of 14 teeth should be present.
- Gender : males and females -Current smokers will be selected (CDC guidelines) -Subjects who give an informed consent to participate in the study.
- Allergic to lycopene or to any of its food sources, especially tomatoes.
- Pregnant and lactating women.
- Patients undergone periodontal therapy in past 6 months.
- Patients under antibiotic/anti-inflammatory drugs.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To assess salivary total antioxidant capacity induced by lycopene on periodontal parameters (Plaque index ,Gingival index ,Probing pocket depth ,Clinical attachment level). baseline, 15th day, 30th day
- Secondary Outcome Measures
Name Time Method To compare the salivary total antioxidant capacity in smokers with periodontits undergoing scaling and root planing alone and undergoing scaling and root planing with systemic administration of lycopene. baseline, 15th day, 30th day
Trial Locations
- Locations (1)
Yenepoya Dental College
🇮🇳Kannada, KARNATAKA, India
Yenepoya Dental College🇮🇳Kannada, KARNATAKA, IndiaJustina David JoyPrincipal investigator8113820865justinadavidjoy@gmail.com