The Serotonergic Transmitter System in Dementia and Affective Disorders

• Conditions: Mood Disorders; Alzheimer Disease

• Registration Number: NCT00192998
• Lead Sponsor: Rigshospitalet, Denmark

Brief Summary

The aim of this project is to examine the serotonergic transmitter system using functional imaging of the brain (positron emission tomography \[PET\]) to gain knowledge about early pathophysiological changes in Alzheimer's dementia and mood disorders.

Detailed Description

Not available

Study Timeline

• Study Start: 2003-10
• Status Verified: 2005-09
• Study First Submitted: 2005-09-13
• Study First Submitted QC: 2005-09-13
• Study First Posted: 2005-09-19
• Last Update Submitted: 2007-09-26
• Last Update Posted: 2007-09-27

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• Moderate to severe Alzheimer's disease
• Individuals genetically predisposed to affective disorder
• Healthy gender and age matched controls

Exclusion Criteria

• Contraindications to magnetic resonance imaging (MRI)
• Use of psychoactive drugs
• Past or present affective disorder
• Other systemic diseases that may affect brain function

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Trial Locations

Locations (1)

Neurobiological Research Unit; 🇩🇰 Copenhagen, Denmark