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临床试验/NCT01272453
NCT01272453已完成不适用

Computed Tomography Dose Reduction Using Sequential or Fast Pitch Sprial Technique Employed in Cardiothoracic Imaging

Gilbert L. Raff, MD9 个研究点 分布在 2 个国家目标入组 2,640 人开始时间: 2011年1月最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
发起方
入组人数
2,640
试验地点
9
主要终点
Radiation dose

研究概览

简要总结

This is a prospective, controlled observational trial of patients undergoing clinically indicated cardiothoracic computed tomography (CT), including pulmonary or aortic angiography and coronary CT angiography (CCTA).

详细描述

The development of a novel CT scanner capable of sequential or fast-pitch spiral techniques in most patients (Siemens Definition Flash) represents a potentially crucial technical innovation at a particularly critical juncture. National healthcare systems are under pressure to deliver accurate and cost-effective diagnosis of an increasing number of patients and CT angiography in various settings is a proven, highly accurate technique that has been shown to improve diagnostic efficiency and reduce the cost of care.

However, there has been increasing concern about the lifetime attributable risk of cancer from radiation related to diagnostic procedures. Such concern extends to other radiation-based procedures that contribute to the cumulative lifetime radiation exposure of patients. The Flash scanner holds the promise of substantially reducing exposure resulting from a variety of examinations.

The CT DOSE multicenter trial is therefore designed to validate the extent of dose reduction attendant to the use of the Flash scanner in cardiothoracic scanning, and to determine whether image quality is preserved in spite of significant dose reduction.

研究设计

研究类型
Observational
观察模型
Case Control
时间视角
Prospective

入排标准

年龄范围
18 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Scans from patients undergoing clinically indicated pulmonary angiography, aortography and/or CCTA.
  • Age greater than or equal to 18 years.

排除标准

  • No exclusions

结局指标

主要结局

Radiation dose

时间窗: Time of CT scan

The primary endpoint is radiation dose, measured as dose-length-product (DLP, in mGy∙cm) and effective radiation dose, calculated as DLP x 0.014 (in mSv).

次要结局

  • Assessment of Image Quality(Time of CT Scan)

研究者

发起方
Gilbert L. Raff, MD
申办方类型
Other
责任方
Sponsor Investigator
主要研究者

Gilbert L. Raff, MD

Medical Director, Advanced Cardiovascular Imaging

William Beaumont Hospitals

研究点 (9)

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