ISRCTN17337128
Completed
未知
Differentiating Alzheimer’s disease, amnestic mild cognitive impairment and normal aging using diffusion kurtosis imaging parameters
Shanghai Jiao Tong University Affiliated Sixth People’s Hospital0 sites60 target enrollmentApril 8, 2019
Overview
- Phase
- 未知
- Intervention
- Not specified
- Conditions
- Alzheimer’s disease, amnestic mild cognitive impairment, normal aging
- Sponsor
- Shanghai Jiao Tong University Affiliated Sixth People’s Hospital
- Enrollment
- 60
- Status
- Completed
- Last Updated
- 4 years ago
Overview
Brief Summary
2019 Results article in https://pubmed.ncbi.nlm.nih.gov/31397353/ (added 02/03/2022)
Investigators
Eligibility Criteria
Inclusion Criteria
- •The AD group was diagnosed according to the following criteria (McKhann et al., 1984\):
- •1\. Based on the Diagnostic and Statistical Manual of Mental Disorders IV and the National Institute of Neurological and Communicative Disorders and Stroke/Alzheimer’s Disease and Related Disorders Association criteria
- •2\. A mini\-mental state examination score of \= 23
- •Petersen diagnostic criteria were used to determine cases of aMCI (Petersen, 2004\), according to:
- •1\. Complaints of memory impairment confirmed by others
- •2\. Objective evidence of memory impairment, e.g., memory test (delayed story recall test) scores lower than (age\- and duration\-) matched healthy controls by 1\.5 standard deviations
- •3\. An overall normal level of cognitive function, i.e., impairment is less than dementia level, Clinical Dementia Rating scale point \= 0\.5
- •4\. Normal daily living skills, according to the Activities of Daily Living scale, mini\-mental state examination score of \< 26 points
- •In the normal control (NC) group, criteria are based on capacity for independence, normal findings on neurological examination and mini\-mental state examination score of \= 28 points.
Exclusion Criteria
- •1\. Patients with history of hypertension, diabetes, mental illness, cancer, autoimmune or other diseases, or alcohol or drug abuse
- •2\. Hachinski Ischemic Scale scores more than 4
Outcomes
Primary Outcomes
Not specified
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