Differentiating Alzheimer’s disease, amnestic mild cognitive impairment and normal aging using diffusion kurtosis imaging parameters

Shanghai Jiao Tong University Affiliated Sixth People’s Hospital0 个研究点目标入组 60 人开始时间: 2019年4月8日最近更新: 2022年3月14日

适应症

试验速览

2019 Results article in https://pubmed.ncbi.nlm.nih.gov/31397353/ (added 02/03/2022)

•The AD group was diagnosed according to the following criteria (McKhann et al., 1984):
•1. Based on the Diagnostic and Statistical Manual of Mental Disorders IV and the National Institute of Neurological and Communicative Disorders and Stroke/Alzheimer’s Disease and Related Disorders Association criteria
•2. A mini-mental state examination score of = 23
•Petersen diagnostic criteria were used to determine cases of aMCI (Petersen, 2004), according to:
•1. Complaints of memory impairment confirmed by others
•2. Objective evidence of memory impairment, e.g., memory test (delayed story recall test) scores lower than (age- and duration-) matched healthy controls by 1.5 standard deviations
•3. An overall normal level of cognitive function, i.e., impairment is less than dementia level, Clinical Dementia Rating scale point = 0.5
•4. Normal daily living skills, according to the Activities of Daily Living scale, mini-mental state examination score of < 26 points
•In the normal control (NC) group, criteria are based on capacity for independence, normal findings on neurological examination and mini-mental state examination score of = 28 points.

•1. Patients with history of hypertension, diabetes, mental illness, cancer, autoimmune or other diseases, or alcohol or drug abuse
•2. Hachinski Ischemic Scale scores more than 4

发起方

Shanghai Jiao Tong University Affiliated Sixth People’s Hospital