Sarcopenia and Cirrhosis
Not Applicable
Completed
- Conditions
- Cirrhosis
- Registration Number
- NCT02132962
- Lead Sponsor
- Rigshospitalet, Denmark
- Brief Summary
The study investigates the effect of aminoacid infusion on proteinturnover in muscle from cirrhosis subjects, compared to healthy controls.
The hypothesis is that aminoacid infusion can attenuate the increase in proteindegradation that follows cirrhosis.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Male
- Target Recruitment
- 17
Inclusion Criteria
- Male subjects
- Diagnosis of cirrhosis, Child-Pugh A, B, C.
Exclusion Criteria
- Acute illness within 3 weeks
- Ascites collections within 10 days
- Heart-, kidney, pulmonary disease. Cancer. Type 1 diabetes.
- Active alkoholdrinking
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Turnover of phenylalanine and tyrosine in skeletal muscle tissue during amino acid infusion. Inflammatory markers. Protein signaling cascade. 24 weeks Using stable isotope tracer technique with infusion of phenylalanine and tyrosine tracer.
Using ELISA technique. Using PCR and western blot technique.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Rigshospitalet
🇩🇰Copenhagen, Denmark
Rigshospitalet🇩🇰Copenhagen, Denmark