Polymorphism of ITGA4 Gene in Chronic Lymphocytic Leukemia
- Conditions
- Chronic Lymphocytic Leukemia
- Registration Number
- NCT05371392
- Lead Sponsor
- Sohag University
- Brief Summary
Chronic lymphocytic leukemia (CLL) is a clonal lymphoproliferative disorder that is characterized by heterogeneous presentation at the clinical and molecular levels. ITGA4 protein has been found to be deregulated in CLL with adverse clinical outcome. ITGA4 gene (CD49d) encodes a member of the integrin alpha chain family of proteins and is considered a negative prognosticator in CLL with aggressive course and short time to treatment.
The aim of the study:
is to investigate ITGA4 gene expression pattern in CLL.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- NOT_YET_RECRUITING
- Sex
- All
- Target Recruitment
- 80
- Patients with newly diagnosed CLL.
-
▪ Patients previously diagnosed as CLL and received treatment before.
- Patients with other solid tumors.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method ITGA4 gene expression pattern in chronic lymphocytic leukemia 1 year following the startpoint of the study Detection of ITGA4 gene expression in blood samples in patients with chronic lymphocytic leukemia, Briefly, total RNA and genomic DNA extraction from fresh peripheral blood samples by Real-time -RT-polymerase chain reaction system (RT-PCR) will be carried out. Rate of ITGA4 gene expression will be recorded.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Sohag university
🇪🇬Sohag, Egypt