Polymorphism of the ITGA4 Gene (Integrin Subunit Alpha 4) in Chronic Lymphocytic Leukemia
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 80
- 试验地点
- 1
- 主要终点
- ITGA4 gene expression pattern in chronic lymphocytic leukemia
研究概览
简要总结
Chronic lymphocytic leukemia (CLL) is a clonal lymphoproliferative disorder that is characterized by heterogeneous presentation at the clinical and molecular levels. ITGA4 protein has been found to be deregulated in CLL with adverse clinical outcome. ITGA4 gene (CD49d) encodes a member of the integrin alpha chain family of proteins and is considered a negative prognosticator in CLL with aggressive course and short time to treatment.
The aim of the study:
is to investigate ITGA4 gene expression pattern in CLL.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Patients with newly diagnosed CLL.
排除标准
- •▪ Patients previously diagnosed as CLL and received treatment before.
- •Patients with other solid tumors.
结局指标
主要结局
ITGA4 gene expression pattern in chronic lymphocytic leukemia
时间窗: 1 year following the startpoint of the study
Detection of ITGA4 gene expression in blood samples in patients with chronic lymphocytic leukemia, Briefly, total RNA and genomic DNA extraction from fresh peripheral blood samples by Real-time -RT-polymerase chain reaction system (RT-PCR) will be carried out. Rate of ITGA4 gene expression will be recorded.
次要结局
未报告次要终点
研究者
Amer Ahmed Youssef Abdalkareem
Specialist of clinical and chemical pathology
Sohag University