EcoHealth approach for dengue control

Not Applicable

Completed

• Conditions: Dengue infection; Infections and Infestations; Dengue

• Registration Number: ISRCTN66131315
• Lead Sponsor: niversité de Montréal

Brief Summary

2020 Protocol article in https://www.ncbi.nlm.nih.gov/pubmed/32059693 protocol (added 17/02/2020) 2023 Results article in https://doi.org/10.1371/journal.pntd.0011110 (added 09/04/2024)

Detailed Description

Not available

Study Timeline

• Study Start: 2018-10-01
• Study Completion: 2022-03-31
• Last Update Posted: 22 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 5440

Inclusion Criteria

Eligibility will be evaluated on three levels: clusters, households, and individual. The inclusion criteria is:
1. Any of the 3,020 census tracts from the 2010 Census
2. Households permanently inhabited
3. Children aged 3 to 9 years

Exclusion Criteria

1. Census tracts where interventions outside of vector control standard practices occurred within the last 5 years
2. Census tracts deemed to insecure for study personnel (determined based upon the opinion of the research team and stakeholders)
3. Clusters with less than 120 households
4. Abandoned or non-permanent households or households with the intention to move outside of the household during the study period
6. Children with chronic disease or other health condition that preclude participation in the study
7. Parents or guardians who are unable to give informed consent

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Measured every 6 months over a 3-year period:<br>1. Rates of anti-dengue Immunoglobin G (IgG) seroconversion (from negative to positive at follow-up) to evaluate the incidence of primary infections, measured using enzyme-linked immunoabsorbent assays (ELISA)<br>2. Level of IgG to N-term-34kDa salivary peptide in blood (salivary biomarkers of Aedes exposure), measured using ELISA<br>3. Pupae per person (number of pupae found per 100 households examined) to evaluate the mosquitoes density/presence, measured by visual inspection

Secondary Outcome Measures

Name	Time	Method
Measured every 6 months over a 3-year period:<br>1. Anti-dengue IgG antibodies waning rates (from positive at baseline to negative at follow-up), measured using ELISA<br>2. Additional entomological indexes, based upon visual inspection<br>3. Self-reported health status and previous fever events, measured using a standardized questionnaire<br>4. Knowledge, attitudes and practices (KAP) changes, measured from focus groups and in-depth interviews<br>5. Household social capital, measured from focus groups and in-depth interviews<br>6. Social acceptability of activities, measured from focus groups and in-depth interviews<br>7. Implementation and adaptability processes, measured from focus groups and in-depth interviews<br>8. Potential for sustainability (intervention), measured from focus groups, in-depth interviews, and document analysis<br>9. Empowerment of individual and communities, measured from focus groups and in-depth interviews