Early Screening of Hepatocellular Carcinoma in Cirrhotic Patients: a Prospective Study
- Conditions
- CirrhosisHepatocellular Carcinoma
- Registration Number
- NCT00629421
- Brief Summary
Although serum alpha-fetoprotein level and abdominal sonography are the main methods to screening hepatocellular carcinoma (HCC) in cirrhotic patients, the adequate time and methods used are not completely well-defined. This study aims to assess the better timing and methods for prospectively screening HCC in patients with cirrhosis
- Detailed Description
Well-diagnosed consecutive patients with cirrhosis were enrolled through a designed questionnaire to obtain basic information about gender, age, etiology of cirrhosis, conventional liver function tests, serum AFP level, education level, substance use including smoking, alcohol drinking, betel quid chewing, history of familial HCC, etc. Then the patients was followed by periodic abdominal sonography examination and determination of AFP and liver function. If AFP elevated or liver nodule appears, effort to diagnose HCC will be performed.If HCC was performed, the survival will be followed-up. As anti-viral therapy was found to decrease risk for HCC, patients with those therapy will be excluded.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 1200
- Image diagnosis or biochemical diagnosis or presence of portal hypertension
- Presence of hepatocellular carcinoma
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method development of hepatocellular carcinoma during observation nodule (with or without seum AFP greater than 400 ng/ml) confirmed by biopsy
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Kaohsiung Medical University Chung-Ho Memorial Hospital
🇨🇳Kaohsiung, Taiwan