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临床试验/NCT05333146
NCT05333146Unknown不适用

Outcomes After Perioperative Stroke Following Cardiac Surgery

University of British Columbia1 个研究点 分布在 1 个国家目标入组 906 人开始时间: 2022年4月18日最近更新:
适应症

试验速览

阶段
不适用
入组人数
906
试验地点
1
主要终点
Death

研究概览

简要总结

Perioperative stroke is a devastating complication of cardiac surgery that is currently poorly characterized but occurs in 1-5% of patients and is associated with poor outcomes including increased mortality. Given the uncommon nature of this complication, relatively little is known about which factors predict these outcomes among those who experience a perioperative stroke. The study objectives are to identify predictors of mortality, length of stay and discharge disposition after perioperative stroke in cardiac surgery using the prospectively-collected American College of Surgeons National Surgical Quality Improvement Program database between 2005 and 2020.

详细描述

BACKGROUND Perioperative stroke is a devastating complication of cardiac surgery that is currently poorly characterized. Perioperative stroke is a cerebrovascular event that occurs after cardiac surgery, and affects between1-5% of patients. The current literature has identified that patients who experience a stroke after surgery have a higher rate of mortality, length of stay and discharge to a facility, but given the rare nature of this complication less is known about which factors predict these outcomes among those who experience a perioperative stroke.

OBJECTIVES

  1. Derive and externally validate risk prediction models for mortality (primary outcome), adverse discharge, and length of stay after perioperative stroke.
  2. Describe temporal trends in mortality after perioperative stroke between 2005 and 2020.

METHODS This study is a retrospective analysis of the prospectively-collected American College of Surgeons National Surgical Quality Improvement Program database between 2004 and 2020. The study cohort will be extracted from the NSQIP database and include all patients who experienced a stroke within 30 days of surgery and who underwent a cardiac surgical procedure.

STUDY POPULATION Patients who underwent any cardiac surgical procedure and who experienced a perioperative stroke in the NSQIP database between 2005 and 2020 will be included.

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Retrospective

入排标准

年龄范围
18 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Experienced a perioperative stroke
  • Underwent cardiac surgery

排除标准

  • 未提供

结局指标

主要结局

Death

时间窗: Within 30 days of surgery

Death

次要结局

  • Adverse discharge(Within 30 days of surgery)
  • Length of stay(Within 30 days of surgery)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Alana Flexman

Principal Investigator

University of British Columbia

研究点 (1)

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