Distinguishing Gastroesophageal Reflux Disease and Eosinophilic Esophagitis in Adults: the Role Esopahegal Mucosal Immunoglobulin IG4

Not Applicable

Completed

• Conditions: Eosinophilic oesophagitis; Gastroesophageal reflux disease; Oral and Gastrointestinal - Other diseases of the mouth, teeth, oesophagus, digestive system including liver and colon; Inflammatory and Immune System - Other inflammatory or immune system disorders

• Registration Number: ACTRN12620000263998
• Lead Sponsor: GI and Pancreatic Researchs Group

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Completion: 2019-12-31
• Study Start: 2020-02-27
• Last Update Posted: 3 March 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

GERD:
-18-80 years of age
-typical symptoms of GERD responsive to PPI therapy
-evidence of oesophagitis on endoscopy with supportive oesophageal biopsy specimens --eosinophil count <10/hpf
EoE:
-18-80 years of age, symptoms of oesophageal dysfunction with 'greater than or equal to' 15 eosinophils/hpf
-exclusion of other causes of eosinophilia

Exclusion Criteria

Exclusion criteria were history of severe respiratory, cardiovascular, hepatic, haematological and/or renal disease, chronic alcohol abuse, medications that may influence gastrointestinal function and previous gastrointestinal surgery.

Study & Design

• Study Type: Observational
• Study Design: Not specified