inking the periphery with the CNS: Do pupil dilation and skin conductance responses correlate with locus coeruleus and amygdala activity?

Recruiting

Conditions: scientific investigation of healthy subjects
healthy

Registration Number: NL-OMON40221

Lead Sponsor: niversiteit Leiden

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: Not specified

Target Recruitment: 24

Inclusion Criteria

Healthy adult subjects with no history of neurological disorder/disease and no counter-indications to 3 and 7 Tesla MRI. All participants will be right-handed with normal vision or contact lenses.

Exclusion Criteria

Potential participants will be pre-screened for contra-indications for 3 and 7 Tesla fMRI, which include metal implants, heart arrhythmia, claustrophobia, and possible pregnancy (in adult females). They will additionally be pre-screened for head trauma, premature birth, learning disabilities, and history of neurological or psychiatric illness and/or use of psychotropic medications. Finally, left-handed individuals will be excluded from the study because some left-handers have substantially different brain organization relative to right-handers.

Study & Design

Study Type: Observational non invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>MRI will be performed at the 3T and at the 7T (for the session 4) scanner<br /><br>located in the radiology department of the LUMC. A specific high-resolution<br /><br>scan sequence, developed for visualizing the brainstem, will be carried out and<br /><br>used for subsequent localization of the fMRI images. Functional images will be<br /><br>acquired with a high-resolution EPI sequence, centered on the brainstem.<br /><br>Simultaneously, pupil diameter will be measured using an EyeLink 1000<br /><br>fMRI-compatible eye tracker and skin conductance and heart rate will be<br /><br>measured with an MRI-compatible MP150 BIOPAC recording device (BIOPAC systems<br /><br>Inc.).</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Saliva will be collected at the beginning of the experimental session for<br /><br>genetic and cortisol analysis. Personality questionnaire measures will be<br /><br>administered to investigate whether the results are mediated by personality<br /><br>factors and mood questionnaire scores will be analyzed to investigate task<br /><br>effects on mood. </p><br>