Introduction of breast cancer prevention with tamoxifen for high risk premenopausal women in the UK (TAMoxifen Prevention study - TAM-P)

Not Applicable

Completed

• Conditions: Breast cancer; Cancer; Malignant neoplasm of breast

• Registration Number: ISRCTN53844391
• Lead Sponsor: niversity Hospital of South Manchester (UK)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2012-10-26
• Study Completion: 2013-11-30
• Last Update Posted: 7 November 2022

Recruitment & Eligibility

• Status: Completed
• Sex: Female
• Target Recruitment: 136

Inclusion Criteria

1. Pre-menopausal
2. Attends the Family History Clinic at the Nightingale & Genesis Prevention Centre
3. At moderate or high risk of breast cancer
4. Normal mammogram
5. Willing to use a non-hormonal form of contraception (mirena coil is permitted)
6. Upper Age Limit 46 years ; Lower Age Limit 33 years

Exclusion Criteria

1. Use of coumarin type anticoagulants
2. Use of droperidol
3. Use of Bupropion
4. Diabetes (type I or II)
5. Use of hormonal contraceptives within 3 monhts of joining the study (mirena coil is permitted)
6. Pregnancy and breastfeeding
7. Prophylactic mastectomy or plans to have this procedure
8. Personal or family history of thromboembolism
9. Previous cancer in the last five years (except basal cell carcinoma or in situ cancer of the cervix)
10. Symptomatic gynaecological problems requiring medication

Study & Design

• Study Type: Interventional
• Study Design: Not specified