A Double-Blind, Placebo-Controlled, Multicenter, Dose-Ranging Study of an Anti-human-T-lymphocyte Immune Globulin (EZ-2053) in the Prophylaxis of Acute Pulmonary Allograft Rejection in Adult Recipients of Primary Pulmonary Allograft(s)
Overview
- Phase
- Phase 3
- Intervention
- Not specified
- Conditions
- Chronic Obstructive Pulmonary
- Sponsor
- Neovii Biotech
- Enrollment
- 223
- Locations
- 19
- Primary Endpoint
- Number of Participants With the Event Death, Graft Loss, Acute Rejection and/or Loss to Follow-up (Whichever Occurred First)
- Status
- Completed
- Last Updated
- 13 years ago
Overview
Brief Summary
The purpose of this study is to assess the efficacy and safety of the study drug, known as "ATG Fresenius S," which is sometimes called "EZ-2053," to prevent a lung transplant patient's body from rejecting a transplanted lung or lungs.
Detailed Description
Patients are generally consented for the study once they go on the lung transplant waiting list and then are re-consented periodically thereafter until they undergo the lung transplant surgery. A pre-surgical assessment consisting of medical history, physical exam, ECG, chest X-Ray, and blood tests are conducted. After lung transplant surgery, patients are assessed for continued eligibility. Within 6-24 hours after the end of surgery, patients are randomized to receive one infusion of study drug or placebo through a central venous catheter. Each day for 5 days following transplant surgery, patients are monitored for transplant rejection, infections, adverse events and laboratory test changes. On post-randomization Days 14, 30, 60, 90, 180, 270 and 365, patients will be monitored for acute transplant rejection, infections and cancer, pulmonary function tests and adverse experiences. Pulmonary biopsies will be performed on post-randomization Days 30, 60, 90, 180 and 365. Blood samples will be drawn during each visit.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Recipient of a primary single or double pulmonary allograft
- •Capable of understanding the purposes and risks of the study and has given written informed consent, and agrees to comply with the study requirements
- •Women of childbearing potential must have a negative serum pregnancy test within 4 days prior to randomization.
Exclusion Criteria
- •Undergoing second or living donor transplant
- •Prior treatment with T-cell depleting agents within the previous 5 years for the purpose of immunosuppression
- •Prior plasma exchange and/or treatment with IVIg within the past 5 years
- •Pulmonary infection with pan-resistant Pseudomonas or any Burkholderia species
- •Known positive blood cultures
- •Donor lung ischemia time \> 8 hours for first lung and \> 8 hours for the second lung
- •Previously received or is receiving a multi-organ transplant
- •Pregnant women, nursing mothers or women of child-bearing potential who are unwilling to use reliable contraception. Effective contraception must be used BEFORE beginning study drug therapy, for the duration of the study and for 6 months following completion of the study
- •Active, extra-pulmonary systemic infection requiring the prolonged or chronic use of antimicrobial agents or the presence of a chronic active hepatitis B or C
- •Active liver disease (liver function tests greater than or equal to 2 times the upper limit of normal)
Outcomes
Primary Outcomes
Number of Participants With the Event Death, Graft Loss, Acute Rejection and/or Loss to Follow-up (Whichever Occurred First)
Time Frame: 12 months
Secondary Outcomes
- Number of Participants With Death or Graft Loss Post-transplant(12 months)
- Number of Participants With Acute Rejection(12 months)
- Number of Participants With Infections and Infestations(12 months)
- Number of Participants With Severe Adverse Events(12 months)
- Pulmonary Function Tests, Total Distance Walked 6 Minute Walk Test(12 months)
- Pulmonary Function Test, Forced Vital Capacity(12 months)
- Pulmonary Function Test, Forced Expiratory Volume in 1 Second(12 months)
- Pulmonary Function Test, Forced Expiratory Flow 25-75(12 months)