Effect of Milk Thistle extract (Silibinin) On circulating unconJugated bilirubin levels and markers for Oxidative stress and inflammation: MOJO study

Not Applicable

Recruiting

• Conditions: Oxidative stress and Inflammation; Cardiovascular Disease; Cardiovascular - Other cardiovascular diseases; Alternative and Complementary Medicine - Herbal remedies

• Registration Number: ACTRN12619001296123
• Lead Sponsor: Endeavour College of Natural Health

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2019-09-19
• Last Update Posted: 30 September 2019

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 65

Inclusion Criteria

1. Adults of any gender between the age of 18 and 65
2. Normal Liver Function result (LFT)
3. Normal Full Blood count (FBC)
4. Random Fasting Blood Glucose level (3.0-7.7 mmol/L.)
5. BMI between 18.5 -29.9
6. Are not pregnant or breast feeding
7. Able to give informed consent

Exclusion Criteria

1. History of Liver Disease
2. History of Alcohol abuse
3. History of Type II Diabetes
4. A history of psychological illness or condition which interferes with their ability to understand or comply with the requirements of the study

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Change in circulating total bilirubin levels (>5µM). This will be done through assessment of free and conjugated plasma bilirubin.[14 days after starting each intervention arm]

Secondary Outcome Measures

Name	Time	Method
Change in antioxidant status (Ferric Reducing Ability of plasma), [14 days];plasma Inflammation (hsCRP),[14 days];plasma lipid profile (LDL:HDL ratio / profile)[14 days];platelet aggregation[14 days];plasma Uric acid levels[14 days]