Peri-surgical observation of nociceptive thresholds during total knee arthroplasty for association with persisting post-surgical pain: an explorative study

Withdrawn

• Conditions: Persisterende post-operatieve pijn; Persisting post-surgical pain; 10005944

• Registration Number: NL-OMON40450
• Lead Sponsor: niversitair Medisch Centrum Sint Radboud

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 11 June 2024

Recruitment & Eligibility

• Status: Withdrawn
• Sex: Not specified
• Target Recruitment: 40

Inclusion Criteria

Patients scheduled for total knee arthroplasty.

Exclusion Criteria

- Patient*s refusal
- Pre-existing neurological or psychiatric illnesses
- Chronic pain syndromes
- Alcohol or drug abuse
- Suspected possibility of delirium
- Difficulties in communication
- Rheumatoid arthritis
- Revision knee surgery or participation in another study
- Pre-surgicaloperative ASA score >3

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Persistent post-surgical pain (PPSP)<br /><br>eQST<br /><br>o Electrical pain threshold (ePT) [mA]<br /><br>o Electrical pain tolerance threshold (ePTT) [mA]<br /><br>Nociceptive Perception thresholds (NPT)<br /><br>o Stimulus amplitude [mA]<br /><br>o Responses to stimuli (perceived/not perceived)<br /><br>o Stimulation time [s] </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Pain intensity (NRS)<br /><br>McMaster Universities Osteoarthritis Index (WOMAC)<br /><br>o Pain scale<br /><br>o Stiffness scale<br /><br>o Functional scale<br /><br>Knee Society Score (KSS)<br /><br>o Functional scale</p><br>