A study evaluating the route of administration of dexmedetomidine and dexamethasone in local anaesthetic in patients receiving nerve block for upper limb surgeries.

Not yet recruiting

• Conditions: Medical and Surgical,

• Registration Number: CTRI/2025/06/088951
• Lead Sponsor: Pravin K

Brief Summary

Title

Comparative Evaluation of Perineural Versus Intravenous Administration of Dexmedetomidine and Dexamethasone as Local Anesthetic Adjuvants in Supraclavicular Brachial Plexus Block

Introduction

Regional anesthesia techniques particularly brachial plexus block BPB are widely used for upper limb surgeries providing effective anesthesia and postoperative analgesia. However the duration of analgesia is often limited leading to rebound pain and increased opioid dependence Adjuvants such as dexmedetomidine and dexamethasone have been introduced to enhance block efficacy but the optimal route of administration remains debated.

Objectives

To compare the efficacy of perineural versus intravenous dexmedetomidine and dexamethasone in BPB.

To evaluate their effects on analgesia duration motor blockade onset and duration postoperative pain sedation hemodynamic stability and patient satisfaction

Methodology

A randomized controlled trial will be conducted with patients undergoing supraclavicular BPB for upper limb surgeries. Participants will be divided into three groups receiving either perineural dexmedetomidine plus IV dexamethasone or perineural dexamethasone plus IV dexmedetomidine or perineural dexamethasone plus IV saline Outcome measures will include analgesia duration sedation levels blood glucose variations and hemodynamic changes tracked over a 48-hour postoperative period

Expected Outcomes

Identification of the most effective administration route for prolonged analgesia and optimal motor blockade

Evaluation of postoperative pain relief and sedation profiles across groups

Recommendations for optimizing regional anesthesia protocols to enhance patient recovery and minimize opioid requirements

Conclusion

This study will provide valuable insights into anesthetic adjuvant optimization contributing to evidence-based anesthesia practices The findings will aid clinicians in choosing the most effective administration route improving patient outcomes and perioperative safety

Detailed Description

Not available

Study Timeline

• Study Start: 2025-06-26
• Last Update Posted: 2025-11-06

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

American Society of Anesthesiologists ASA physical status I II or III who were scheduled for elective upper extremity surgery under supraclavicular BPB Both elective and emergency surgeries.

Exclusion Criteria

Contraindication for BPB Refusal to consent severe coagulopathy sepsis infection at the block site Preexisting neuropathy of the surgical limb Pregnancy BMI more than 35 kg per m2 Patient on an alpha agonist as a hypertensive medication Uncontrolled Diabetes Mellitus RBS more than 250 mg per dl Actual body weight less than 40 kg.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Primary outcome:	Primary outcome: | Duration of analgesia time between block completion and the first request for analgesic supplementation | Secondary outcomes | 1Includes motor block duration defined as the time between block completion and complete resolution of the motor block; a score of 2 in the 3-point modified Bromage score | 2.The duration of sensory blockade is defined as the time between block completion (withdrawal of block needle) and resolution of sensory block (Temperature) at the dermatomal level of C5). | 3.Sensory block onset (time between block completion and sensory block (Temperature) at the dermatomal level of C5). | 4.Motor block onset (time between block completion and achieving score of 1 in 3-point modified Bromage Scale);
Duration of analgesia time between block completion and the first request for analgesic supplementation	Primary outcome: | Duration of analgesia time between block completion and the first request for analgesic supplementation | Secondary outcomes | 1Includes motor block duration defined as the time between block completion and complete resolution of the motor block; a score of 2 in the 3-point modified Bromage score | 2.The duration of sensory blockade is defined as the time between block completion (withdrawal of block needle) and resolution of sensory block (Temperature) at the dermatomal level of C5). | 3.Sensory block onset (time between block completion and sensory block (Temperature) at the dermatomal level of C5). | 4.Motor block onset (time between block completion and achieving score of 1 in 3-point modified Bromage Scale);

Secondary Outcome Measures

Name	Time	Method
Secondary outcomes	1Includes motor block duration defined as the time between block completion and complete resolution of the motor block; a score of 2 in the 3-point modified Bromage score

Trial Locations

Locations (1)

AIIMS Guwahati; 🇮🇳 Kamrup, ASSAM, India

AIIMS Guwahati

🇮🇳Kamrup, ASSAM, India

Pravin k

Principal investigator

09543735226

ksppravin58@gmail.com