Evaluation of Optimal Time of Methimazole Discontinuation Before Radio-iodine Therapy in Hyperthyroid Grave's Patients

Not Applicable

Completed

• Conditions: Graves Disease
• Interventions: Drug: Methimazole

• Registration Number: NCT01560299
• Lead Sponsor: Mashhad University of Medical Sciences

Brief Summary

Iodine therapy is the best treatment for graves disease.Most patients receive methimozale prior to radio-iodine treatment. This may decrease treatment response to iodine therapy.

Some physicians advice to discontinue methimazole 3 days before radioiodine therapy and others prefer longer off - methimazole period which bothers most patients. This study aimed to evaluate optimum time for methimazole discontinuation in graves disease.

Detailed Description

Not available

Study Timeline

• Study Start: 2010-02
• Primary Completion: 2012-01
• Study Completion: 2012-01
• Status Verified: 2012-03
• Study First Submitted: 2012-03-01
• Study First Submitted QC: 2012-03-20
• Last Update Submitted: 2012-03-20
• Study First Posted: 2012-03-22
• Last Update Posted: 2012-03-22

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 150

Inclusion Criteria

• age 18-65
• graves disease(TSH<0.1 &increased FT4 & positive TSI
• one or more bartlena criteria for radio-iodine therapy
• 24 hour RAIU>25%
• euthyroidism after methimazole treatment

Exclusion Criteria

• pregnancy or lactation
• moderate or severe graves ophthalmopathy
• CHF or coronary heart disease
• palpable thyroid nodule
• lithium or amiodarone or lugol or ipodate treatment
• recent imaging with contrast agent
• very large goiter(more than 150 gram)

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: FACTORIAL

Arm && Interventions

Group	Intervention	Description
group one	Methimazole	This group will be advised to discontinue methimazole 24-48 hour before iodine therapy
group two	Methimazole	methimazole stopped 48-72 hour before radioiodine therapy
group three	Methimazole	-

Primary Outcome Measures

Name	Time	Method
thyroid function tests over one year after radioiodine therapy	months 1 , 3 ,6,9,12	thyroid function test may change over one year . In order to consider the patients as cured ,thyroid function tests should reveal hypothyroidism or euthyroidism . In order to rule out temporary hypothyroidism the tests should be repeated after 6 months of radioiodine therapy.

Trial Locations

Locations (1)

Mashad University of Medical Sciences; 🇮🇷 Mashad, Khorasan Razavi, Iran, Islamic Republic of