Evaluation of Optimal Time of Methimazole Discontinuation Before Radio-iodine Therapy in Hyperthyroid Grave's Patients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 150
- 试验地点
- 1
- 主要终点
- thyroid function tests over one year after radioiodine therapy
研究概览
简要总结
Iodine therapy is the best treatment for graves disease.Most patients receive methimozale prior to radio-iodine treatment. This may decrease treatment response to iodine therapy.
Some physicians advice to discontinue methimazole 3 days before radioiodine therapy and others prefer longer off - methimazole period which bothers most patients. This study aimed to evaluate optimum time for methimazole discontinuation in graves disease.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Factorial
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •age 18-65
- •graves disease(TSH<0.1 &increased FT4 & positive TSI
- •one or more bartlena criteria for radio-iodine therapy
- •24 hour RAIU>25%
- •euthyroidism after methimazole treatment
排除标准
- •pregnancy or lactation
- •moderate or severe graves ophthalmopathy
- •CHF or coronary heart disease
- •palpable thyroid nodule
- •lithium or amiodarone or lugol or ipodate treatment
- •recent imaging with contrast agent
- •very large goiter(more than 150 gram)
研究组 & 干预措施
group one
This group will be advised to discontinue methimazole 24-48 hour before iodine therapy
干预措施: Methimazole (Drug)
group two
methimazole stopped 48-72 hour before radioiodine therapy
干预措施: Methimazole (Drug)
group three
干预措施: Methimazole (Drug)
结局指标
主要结局
thyroid function tests over one year after radioiodine therapy
时间窗: months 1 , 3 ,6,9,12
thyroid function test may change over one year . In order to consider the patients as cured ,thyroid function tests should reveal hypothyroidism or euthyroidism . In order to rule out temporary hypothyroidism the tests should be repeated after 6 months of radioiodine therapy.
次要结局
未报告次要终点
研究者
S.R.ZAKAVI
associate professor
Mashhad University of Medical Sciences