Gut bacteria targeted therapy for metabolic syndrome Post-Liver Transplant

Not Applicable

• Conditions: Diet and Nutrition - Obesity; Metabolic and Endocrine - Diabetes; Metabolic syndrome post liver transplant; Metabolic and Endocrine - Other metabolic disorders

• Registration Number: ACTRN12613001002774
• Lead Sponsor: David Orr

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2013-09-10
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: ot yet recruiting
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

Post Liver transplant (>6-months post transplant)
Glucose intolerance or type II diabetes (or liver biopsy proven NAFLD)
Age 18-75.
BMI >27kg/m2

Exclusion Criteria

alcohol consumption>20g/d,
decompensated liver disease,
chronic gastrointestinal disease,
pregnancy,
severe medical conditions,
allergy to eggs/nuts,
medications known to cause steatohepatitis.
renal dysfunction eGFR <40ml/min

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Sustained weight loss of >7% initial body weight on calibrated digital scales.[Week 16]

Secondary Outcome Measures

Name	Time	Method
Reduced liver fat as ascetained by fibroscan CAP[16 weeks];Reduced insulin resistance (HOMA-IR)[Week 16];Reduced ALT on serum assay[16 Weeks];Reduced cholesterol on serum assay[Week 16]