Clinical Comparative Evaluation of the Use of Photodynamic Therapy in Conjunction With the Use of Vitamin D in Management Stage II Grade B Periodontitis Patients

Not Applicable

Recruiting

• Conditions: Vitamin D Deficiency

• Registration Number: NCT06700122
• Lead Sponsor: Cairo University

Brief Summary

Clinical Comparative Evaluation of the use of Photodynamic Therapy in conjunction with the use of Vitamin D in management Stage II Grade B Periodontitis Patients: A Randomized controlled clinical trial.

Detailed Description

This randomized clinical trial evaluates the effect of Photodynamic therapy alone with SRP versus Photodynamic therapy with SRP and Vitamin D regarding Clinical evaluation

1. Clinical attachment loss (CAL)

2. Probing pocket depth (PPD)

3. Bleeding on probing (BOP)

Study Timeline

• Study First Submitted: 2024-11-19
• Study First Submitted QC: 2024-11-19
• Study First Posted: 2024-11-21
• Status Verified: 2025-04
• Last Update Submitted: 2025-04-13
• Last Update Posted: 2025-04-15
• Study Start: 2025-06-01
• Primary Completion: 2025-06-15
• Study Completion: 2025-06-15

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 24

Inclusion Criteria

• Systemic healthy patients
• Patients aged > 25 years
• Patients suffering from stage II periodontitis with grade B were included in this study, according to 2017 world workshop classification of periodontal disease.
• Patients with interdental clinical attachment loss (CAL) of 3-4 mm with radiographic evidence of bone loss extending to coronal third of the root.
• Radiographic bone loss (RBL) will be diagnosed using periapical parallel technique using 6 radiographic images for full mouth (3- radiographic images for maxillary arch and 3- radiographic images for mandibular arch) including anterior, canine region and posterior teeth at baseline for diagnosis.
• No history of previous periodontal therapy.
• No taken medications known to interfere healing or periodontal tissue health such as anticonvulsants, calcium channel blockers, or immunosuppressant drugs.
• No previous periodontal surgery at involved sites.
• Good oral hygiene and good compliance with the plaque control instructions following initial therapy.
• Neither taken antibiotics within the last three months nor nonsteroidal anti-inflammatory drugs within the last three months
• Absence of diseases or conditions that would interfere with wound healing such as diabetes mellitus or coagulation disorders

Exclusion Criteria

Patients taking Vitamin D as a nutritional supplement were excluded from the study

• Smoking habits
• Pregnant and lactating mothers
• Patients who have been received periodontal surgery in the study area during the last 6 months.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Clinical attachment level (CAL)	Day 0 - Week 6	CAL will be measured form cemento- enamel junction (CEJ) to the depth of the pocket using UNC periodontal probe.; • It will be recorded at 6 sites per tooth, the recorded readings will be used to generate mean values at each time point.

Secondary Outcome Measures

Name	Time	Method
Probing Pocket Depth (PPD)	Day 0 - Week 6	PPD will be measured form free gingival margin (FGM) to the depth of the pocket using UNC periodontal probe.
Bleeding on probing (BOP)	Day 0- Week 6	Assessment after 30 seconds after gentle brushing of the sulcus with a periodontal probe, measurement quadrant

Trial Locations

Locations (1)

Marwa Helal; 🇪🇬 Cairo, Egypt