Phase 4 Study of Patients Receiving BNP or NTG (IV) During Angioplasty, Re-examined 24 Hours Later Using the Flow-mediated Brachial Artery Dilation Study, and Blood Assays for Pro BNP and ET1

The Baruch Padeh Medical Center, Poriya2 个研究点分布在 1 个国家目标入组 500 人开始时间: 2005年7月1日最近更新: 2011年8月9日

适应症

试验速览

阶段: 4 期
发起方: The Baruch Padeh Medical Center, Poriya
入组人数: 500
试验地点: 2
主要终点: FMD

研究概览研究设计入排标准结局指标研究者研究点记录与标识符相似试验

研究概览

简要总结

Patients receiving BNP or nitroglycerin (IV) during the angioplasty procedure. 24 h after the procedure, vascular reactivity will be re-examined using the brachial artery flow-mediated dilatation study. Blood assays for ET-1, pro-BNP, and various inflammatory markers will be checked before and 24 h after the procedure. It is our hypothesis that endothelial function will be better in the BNP treated patients compared to the NTG treated patients

研究设计

研究类型: Interventional
分配方式: Randomized
干预模型: Single Group
主要目的: Supportive Care
盲法: Double (Participant, Outcomes Assessor)

入排标准

性别: All
接受健康志愿者: 否

入选标准

•coronary artery disease -

排除标准

•CHF and/or reduced LV function, or renal failure with Creatinine >2mg%

结局指标

主要结局

FMD

时间窗: 3 years

次要结局

未报告次要终点

研究者

发起方

The Baruch Padeh Medical Center, Poriya

申办方类型

Other Gov

研究点 (2)

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