Early Detection of Contrast Induced Nephropathy After Coronary Angiography : Predictive Value of Osteopontin
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 155
- 主要终点
- early detection of patients at risk of (CA-AKI) before angiographic procedures
研究概览
简要总结
Early detection of contrast induced nephropathy by using osteopontin as an early marker for prediction
详细描述
People who undergo coronary angiography are at risk of contrast-associated acute kidney injury (CA-AKI) .
The prevention therapy is the main approach to address CA-AKI, minimizing the volume of contrast media and intravenous hydration before and after the procedure which may not be appropriate for those with heart failure .
Given limited treatment options once CA-AKI develops and an unfavourable associated prognosis, early identification of those at risk of CA-AKI is crucial.
Also, there is studies was linking CA-AKI with a higher mortality rate and adverse future cardiovascular events, and risk for future CA-AKI events .
Mehran and colleagues described CA-AKI risk score predicting both CA-AKI and cardiovascular events after angiographic procedures.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients undergoing coronary with or without intervention between 2022and 2024 were prospectively enrolled at the study.
- •Patients were referred for angiography for various acute and nonacute indications, including acute coronary syndromes, heart failure, abnormal stress tests, stable chest pain, claudication, and routine preoperative evaluation.
- •Patient with CKD stage 1 or 2 only
排除标准
- •Pt has history of contrast induced nephropathy before. Patient known to have Chronic kidney disease stage 3A upto 5D Pt has contraindication for coronary angiograghy.
结局指标
主要结局
early detection of patients at risk of (CA-AKI) before angiographic procedures
时间窗: Baseline
Early prediction of CIN for early prevention and proper management
次要结局
未报告次要终点
研究者
Noura gamal
Director,assistant lecture,principle investigator.clinical physician.
Assiut University