EUCTR2009-014643-36-BE进行中（未招募）1 期
Effects Of The Administration Of Nebivolol Versus Carvedilol On Microcirculatory Endothelial Function, Arterial Stiffness And Wave Reflection In Healthy Volunteers” (NeCaMic-study) - NeCaMic
MENARINI Benelux NV/SA0 个研究点开始时间: 2010年3月15日最近更新:
适应症
相关药物
试验速览
- 阶段
- 1 期
- 状态
- 进行中（未招募）
- 发起方
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional clinical trial of medicinal product
入排标准
入选标准
- •Male volunteers
- •= 18 year old at the randomisation visit and = 75 year old
- •Normotensive volunteers : SBP <140mm Hg and DBP < 90
- •Caucasians volunteers
- •Given informed consent
- •Normal sinus rhythm with FC >60 BPM
- •Are the trial subjects under 18? no
- •Number of subjects for this age range:
- •F.1.2 Adults (18-64 years) yes
- •F.1.2.1 Number of subjects for this age range
- •F.1.3 Elderly (>=65 years) no
- •F.1.3.1 Number of subjects for this age range
排除标准
- •Cardiovascular disease (such as unstable angina, sick sinus syndrome,
- •heart failure with LVEF < 50%, valvular disease, unstable ischemic heart
- •disease, antecedent of ventricular arrhythmia, syncope, branch block on
- •the ECG, …) if clinically significant, at the discretion of the Investigator
- •Myocardial infarction or cerebrovascular event within the previous 3
- •Use of any medication during the trial
- •Use of non ocular ß-blockers within the previous month
- •Chronic obstructive pulmonary disease (COPD) or bronchial asthma
- •Severe peripheral vascular disease
- •Diabetes mellitus type 1 or type 2
- •serum creatinine >2.5 mg/dl
- •Creatinine clearance< 50 ml/ min
- •Disabling or terminal illness
- •History of sensitivity or significant adverse reactions to ß-blocker therapy
- •Severe obesity (Body Mass Index>35 kg/m²)
- •Cannabis or other drug abuse
- •Use of anti-inflammatory drugs within the past 2 weeks even topically
- •Excessive use of Alcohol (at the discretion of the Investigator)
研究者
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