Effects of actual and imagined music-cued gait training on motor functioning and brain activity in people with multiple sclerosis: a multicentre study - RIGMUC

Medizinische Universität Innsbruck0 个研究点目标入组 147 人开始时间: 2020年12月28日最近更新: 2024年8月19日

适应症

试验速览

暂无简介。

•People with any MS phenotype according to the revised McDonald’s criteria; aged 18 years or over; any ethnicity; disability status score on the EDSS of 2.0 to 5.0; stable disease; no evidence of disease activity; and able to speak and understand German language.
•Healthy controls for the fMRI scanning: 15 age- and gender matched healthy controls without any history of neurological, psychiatric, orthopaedic or other disorder.

•People with MS with concomitant diseases (such as malignant diseases, other neurological or psychiatric disorders, musculoskeletal problems affecting walking, pain, uncorrected visual or hearing impairment); cognitive impairment as defined by a MoCA cut-off score of 26/30 (<26 = impaired cognition; =26 = intact cognition); anxiety or depression as signified by a HADS anxiety subscale score of 11/21 or a depression subscale score of 11/21 or suicidality as evaluated by a narrative screening; pregnancy; a relapse of MS within the last three months; any medication initiation or change (including corticosteroids) or any physiotherapy change within three months prior to the study; any change of symptomatic treatment affecting walking (medication or physiotherapy) or of disease modifying treatment (DMT) during the study will lead to an exclusion of the participant from the further analysis.
•Any MRI/fMRI contraindications, e.g. implanted ferrous metal, heart pacemaker or claustrophobia.

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