EFFICACY OF PLATELET DERIVED GROWTH FACTOR GEL IN THE TREATMENT OUTCOME OF DENTINAL HYPERSENSITIVITY - A CLINICAL STUDY.

Dentin hypersensitivity is characterized by short, sharp pain arising from exposed dentine in response to stimuli, typically thermal, evaporative, tactile, osmotic or chemical and which cannot be ascribed to any other dental defect or pathology.

Periodontal attachment loss could be an earlier indicator or a possible risk factor of dentin hypersensitivity . The management of dentinal hypersensitivity is primarily aimed at occluding the dentinal tubules or making coagulates inside the tubules. “At home†desensitizing agents include toothpastes, mouthwashes and chewing gums.

Root biomodifying agents has been advocated as an effective way to remove the smear layer and condition the roots for better regeneration. Root biomodification uses acid substances or chelating agents to remove the smear layer and expose root collagen fibers.

Platelet derived gowth factor (PDGF) stimulates angiogenesis, promotes cell migration into the bone defect from the surrounding tissue margins, and upregulates cell proliferation.The matrix, in addition to its role as a growth factor delivery vehicle, provides mechanical support for migrating cells and contributes to the formation of new bone, cementum and/or periodontal ligament.

Novamin® (calcium sodium phosphosilicate) is one such material, which reacts when exposed to the body fluids, and deposits hydroxycarbonate apatite, a mineral that is chemically similar to the mineral in enamel and dentin6.

Thus, the present study will be conducted to evaluate and compare effectiveness of recombinant human platelet derived growth factor gel and novamin desensitizing tooth paste in subjects with dentinal hypersensitivity.