Concurrent Transcranial Direct Current Stimulation and Gait Training in Parkinson's Disease

Not Applicable

• Conditions: Parkinson's Disease
• Interventions: Other: Active tDCS plus gait training; Other: Sham tDCS plus gait training

• Registration Number: NCT04041661
• Lead Sponsor: National Yang Ming Chiao Tung University

Brief Summary

To investigate the effect of concurrent transcranial direct current stimulation and gait training on gait performance when doing the cognitive dual-task in people with Parkinson's Disease.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2019-07-31
• Study First Submitted QC: 2019-07-31
• Status Verified: 2019-08
• Study Start: 2019-08-01
• Study First Posted: 2019-08-01
• Last Update Submitted: 2019-08-02
• Last Update Posted: 2019-08-06
• Primary Completion: 2020-08-31
• Study Completion: 2020-08-31

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• Diagnosed with idiopathic PD
• Hoehn and Yahr stages I-III
• Mini Mental Status Examination (MMSE) score ≧ 24
• Could walk 10m independently with or without gait aid

Exclusion Criteria

• Concurrent medication likely to affect mental performance
• tDCS contraindication
• Significant neurological, vestibular, visual disorders or psychiatric illness
• Musculoskeletal or cardiopulmonary disease
• Sensory system pathology

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Active tDCS plus gait training group	Active tDCS plus gait training	Participants in Active tDCS plus gait training group will execute Active tDCS on left dorsolateral prefrontal cortex which combined with treadmill, 12 times per week, least 4 weeks.
Sham tDCS plus gait training group	Sham tDCS plus gait training	Participants in Sham tDCS plus gait training group will executeSham tDCS on left dorsolateral prefrontal cortex which combined with treadmill, 12 times per week, least 4 weeks.

Primary Outcome Measures

Name	Time	Method
Dual-task walking performance	Change from baseline at 4 weeks	To evaluate gait parameters while doing dual-task walking

Secondary Outcome Measures

Name	Time	Method
Single walking performance	Change from baseline at 4 weeks	To evaluate gait parameters while doing single walking
Digit span test	Change from baseline at 4 weeks	To evaluate executive function
Stroop color and word test-Chinese version	Change from baseline at 4 weeks	To evaluate executive function
Trail-making test A & B	Change from baseline at 4 weeks	To evaluate executive function