Assessment and Identification of Proprioceptive and Functional Changes in Patients With Hemophilia of the Region of Murcia.
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Assess the range of motion
研究概览
简要总结
Analyze and evaluate the skeletal muscle of patients affected with hemophilia in the Region of Murcia.
- Describe the periarticular muscular deficit of the lower limbs, depending on the degree of injury: acute and chronic, or subacute.
- Identify the range of motion of joints with higher prevalence of hemophilic arthropathy.
- Detect the biomechanical changes of the lower limbs and their impact on gait in patients with hemophilia.
- Assess the factors that influence the perception of illness and quality of life of patients with hemophilia.
详细描述
Descriptive study of joint involvement in hemophilia patients with and without a history of hemarthrosis in lower limbs.
Descriptive study of alterations in the strength of the periarticular muscles of lower limbs as a result of acute conditions or the development of chronic articular sequelae.
Descriptive study of the biomechanical alterations in weight-bearing joints of lower limbs and their impact on gait in patients with hemophilia.
Descriptive study of the relationship between skeletal muscle pathology in patients with hemophilia and their perceptions of it and their quality of life.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 6 Years 至 70 Years（Child, Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Patients with hemophilia A and B
- •Patients of all ages (from 6 to 70 years).
- •With or without joint damage clinically diagnosed, and with or without a previous history of hemarthrosis joint load legs.
- •Residents in the Autonomous Community of the Region of Murcia.
排除标准
- •Patients without ambulation
- •Patients diagnosed with other congenital coagulopathy (von Willebrand disease, etc..).
- •Patients with neurological or cognitive impairments that prevent understanding the questionnaires and physical tests.
结局指标
主要结局
Assess the range of motion
时间窗: Screening visit
Assess the range of motion of elbow, knee and ankle (using a goniometric evaluation).
Assess the muscular strength
时间窗: Screening visit
Assess the muscular strength of arm, thigh and leg (through measurement of muscle balance).
Assess the joint pain
时间窗: Screening visit
Joint pain (VAS scale with the use of a pressure algometer).
Assess the variables of strength
时间窗: Screening visit
Assessment of variables of vertical strength, medio-lateral and anterior-posterior in jump and incorporation from the sitting position.
Assess the peak force
时间窗: Screening visit
Functional assessment of peak force, force production per unit time and subsequent stabilization in standing (in jump and in the passage from the sitting position to standing position, respectively, using a force platform).
Assess the contractile activity
时间窗: Screening visit
Assessment of miotendinous contractile activity in the patellar tendon and Achilles, in jump (CMJ-stiffness test).
Assess the state joint
时间窗: Screening visit
State joint (applying Hemophilia Joint Health Score questionnaire).
Assess the list of activities
时间窗: Screening visit
List of activities in hemophilia (completing the autocuestionario Hemophilia Activities List).
Assess the physical performance
时间窗: Screening visit
Perception of physical performance (with the HEP-Test-Q questionnaire)
Assess the health Profile
时间窗: Screening visit
Health Profile (using the scale Nottingham health profile)
Assess the quality of life
时间窗: Screening visit
Quality of life (using the SF-36 and Haemo-QoL-36 questionnaire).
次要结局
- Age, sex, weight of the patients with hemophilia(Screening visit)
- Diagnosis, severity of hemophilia, type of treatment (prophylactic or on-demand) and inhibitors(Screening visit)
- Frequency of joint bleeds in the previous month and bleeding during the assessment(Screening visit)
研究者
RUBÉN CUESTA-BARRIUSO
PhD
Universidad Católica San Antonio de Murcia