Shear Wave Elastography in Differentiating Acute or Chronic Kidney Disease

Recruiting

• Conditions: Elastography; Chronic Kidney Diseases
• Interventions: Diagnostic Test: Shear wave elastography to distinguish AKI from normal kidney; Diagnostic Test: Shear wave elastography to distinguish AKI from CKD; Diagnostic Test: Shear wave elastography to distinguish CKD from normal kidney

• Registration Number: NCT04404114
• Lead Sponsor: National Taiwan University Hospital

Brief Summary

Chronic kidney disease is a common global public health issue and its prevalence increased year by year. Early diagnosis and intervention can prevent further complications and comorbidities of long-term dialysis, cardiovascular events and mortality as well as improve the patients' life quality. To differentiate acute from chronic kidney disease was crucial especially in the setting of crowded and high-risk emergency department. To diagnose acute or chronic kidney disease, physicians usually use blood sample test combined with image studies such as conventional sonography, CT and MRI. However, there was lots of limited factors. The patients may have no previous visit records, poor renal function to receive contrast medium, or critical clinical condition to undergo time-wasting exam. Although the conventional renal sonography is accessible and inexpensive, the judgement is subjective and provide little clinical information. Recent researches of shear wave elastography in evaluating renal parenchymal stiffness showed some correlation with nephropathy. In our study, aiming to facilitating clinical implication, the investigators will use swear-wave elastography combined with conventional renal sonography to benefit patients in diagnosis of acute or chronic kidney disease.

Detailed Description

This is a case-control study. The investigators obtained data from participants who were older than 20 years old and received renal sonography examination in the emergency department of National Taiwan University Hospital. The investigators examined the participants' kidneys by recording the kidney size, cortical thickness, possible lesions and elasticity by shear-wave elastography. These data combined with the participants' medical history and renal function revealed by blood examination will be analyzed. This study was designed to determine the correlation between renal cortical elasticity and chronic kidney disease.

Study Timeline

• Study Start: 2020-02-01
• Study First Submitted: 2020-04-28
• Study First Submitted QC: 2020-05-21
• Study First Posted: 2020-05-27
• Status Verified: 2023-08
• Last Update Submitted: 2023-08-15
• Last Update Posted: 2023-08-16
• Primary Completion: 2023-12
• Study Completion: 2023-12

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 800

Inclusion Criteria

• The patients older than 20 years old who needed to receive renal sonography in emergency department of National Taiwan University Hospital.

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Exclusion Criteria

• The patients who didn't obtain agreement.
• The patients who can't cooperate or follow the directions

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Normal renal function	Shear wave elastography to distinguish AKI from normal kidney	Normal renal function
Acute kidney injury in chronic kidney disease	Shear wave elastography to distinguish AKI from CKD	Acute kidney injury in chronic kidney disease
Acute kidney injury in normal kidney	Shear wave elastography to distinguish AKI from normal kidney	Acute kidney injury in normal kidney
Chronic kidney disease	Shear wave elastography to distinguish CKD from normal kidney	Chronic kidney disease

Primary Outcome Measures

Name	Time	Method
To determine the correlation of kPa ratio and renal function in chronic renal disease	change in renal function after 2 weeks	The analysis will be conducted to determine the correlation between kPa ratio measured by elastography and renal function in patients with chronic renal disease

Trial Locations

Locations (1)

National Taiwan University Hospital; 🇨🇳 Taipei, Taiwan